No registrations found.
ID
Source
Brief title
Health condition
allergic rhinitis related to house dust mite allergy
Sponsors and support
Intervention
Outcome measures
Primary outcome
Mean rhinitis symptom score in September-December after 2 years of SLIT / placebo.
Secondary outcome
(all in September-December after 2 years of SLIT/placebo, except last outcome below)
1. Proportion of symptomfree days;
2. Proportion of days without recue medication;
3. Mean eye symptom score;
4. Total symptom score;
5. Rhintis specific quality of life questionnaire (PARQLQ);
6. Overall assessment of perceived benefit by child and parent over whole period.
Background summary
N/A
Study objective
Null hypothesis: sublingual immunotherapy with house dust mite allergen is as effective as placebo on daily symptoms in children with allergic rhinitis.
Intervention
Sublingual immunotherapy (SLIT) with house dust mite allergen during 24-26 months.
P.O. Box 1738
H. Moed
Molewaterplein 40
Rotterdam 3000 DR
The Netherlands
+31 (0)10 4088194
h.moed@erasmusmc.nl
P.O. Box 1738
H. Moed
Molewaterplein 40
Rotterdam 3000 DR
The Netherlands
+31 (0)10 4088194
h.moed@erasmusmc.nl
Inclusion criteria
1. Age: 6-18 years;
2. History of allergic rhinitis for at least one year;
3. Positive RAST for house dust mite allergy (¡Ý2+);
4. No use of nasal steroids in month before start of baseline measurements;
5. Symptom score of at least 4/12 (four nasal symptoms with scores ranging 0-3);
6. Informed consent.
Exclusion criteria
1. Severe asthma;
2. Allergic sensitivity to pets, in case these are present in the family home;
3. Planned surgery of nasal cavity in the course of the study;
4. Having received immunotherapy in past three years;
5. Contraindications to sublingual immunotherapy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL346 |
| NTR-old | NTR385 |
| Other | : N/A |
| ISRCTN | ISRCTN91141483 |