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ID
Source
Brief title
Health condition
Patients suffering from intermittent claudication are followed during exercise on a standard treadmill. Experiments are repeated after antioxidant suppletion (vitamins E & C).
Sponsors and support
Maxima Medical Center, Eindhoven/Veldhoven
Intervention
Outcome measures
Primary outcome
Levels of 'new' parameters of oxidative stress like isofuranes and halogenated phospholipids are determined. Also vascular parameters (fibrinogen, PAI-1 activity etc) and endothelial damage parameters (soluble thrombomodulin, von Willebrand factor etc) are determined. New techniques like multivariate NMR will be determined for their usefulness in the above mentioned type of studies.
Secondary outcome
N/A
Background summary
The feasibility to use new techniques like multivariate NMR in studies on oxidative stress in vascular diseases is determined. Patients suffering from claudication intermittens are followed during exercise on a standard treadmill. Under these conditions the patients are exposed to an increased level of oxidative stress. Levels of 'new' biomarkers for oxidative stress are compared with levels of more traditional biomarkers for this condition. New techniques like multivariate NMR are examined for their usefulness in the above mentioned type of studies.
Study objective
Multivariate Nuclear Magnetic Resonance (NMR) can be used to measure oxidative stress in patients suffering from intermittent claudication.
Study design
N/A
Intervention
Patients will receive antioxidant supplementation with high concentrations of vitamin E (200 mg/day) and vitamin C (1000 mg/day) during 4 weeks.
Inclusion criteria
Stable (more than 6 months regarding subjective walking distance) patients with claudication intermittens.
Exclusion criteria
Patients with pre-existing renal dysfunction and those not able to perform a standard walking test.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL353 |
| NTR-old | NTR392 |
| Other | : METC 0114 / 0112 X |
| ISRCTN | ISRCTN69086952 |