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ID
Source
Brief title
Health condition
complicated respiratory tract infections, COVID-19
Sponsors and support
Intervention
Outcome measures
Primary outcome
Quality of life (SF-36)
Secondary outcome
episodes of respiratory infections requiring antibiotic prescription, number of contacts with GP, exacerbations of chronic disorders, hospital referrals, mortality within 12 months, severity and duration of physical complaints, risk factors for delayed clinical recovery, mental complaints or mental disorders, exercise tolerance.
Background summary
Introduction: While we learn now that complicated COVID-19 respiratory tract infections in hospitalised patients can cause long lasting lingering symptoms, both somatically and psychologically, the long term impact of complicated COVID-19 respiratory tract infections managed at home is still unknown. Knowledge on the prognosis of patients with a complicated COVID-19 respiratory tract infection is important in order to improve follow-up and adequate support of these patients.
Methods: 274 patients with a complicated respiratory tract infection, presenting at the GP between March 1 and June 1 2020 are eligible for inclusion. After informed consent, a venous blood sample for SARS-CoV-2 serology will be taken. Follow-up on patients is performed every 3 months with SF-36 by telephone. Besides, follow-up will focus on signs, symptoms, use of medication, contacts with health care professionals, dyspnea score by Medical Research Council dyspnea questionnaire, exercise tolerance, daily activities and quality of life assessment by SF-36.
12 months after the index consultation extraction of data from medical files of included subjects will take place on: contacts with the health centre and the indication for contact, signs and symptoms, additional testing for possible COVID-19 related complaints (e.g. cough, dyspnea, chest pain, fatigue, impaired exercise tolerance), use of medication, referrals to other health care professionals including psychologist or psychiatrist, outcomes on treatment or diagnostic procedures outside the health centre and mortality.
Study objective
Patients with respiratory tract infections fromo COVID-19 experience more often long lasting complaints
Study design
3-6-9-12 months after consulting the GP
Intervention
n.a.
Inclusion criteria
Patients at least 18 years of age, with a history of a complicated respiratory tract infection, between March 1st and June 1st 2020 in primary care, who were not admitted to the hospital.
Exclusion criteria
Patients with a life expectancy of <1 year, patients who were hospitalized in the previous 14 days before the index consultation at the COVID-19 centre, patients not capable of performing telephone interviews, patients who were hospitalised within 14 days after the index consultation.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
| Register | ID |
|---|---|
| NTR-new | NL8729 |
| Other | METC UMCU : volgt |