No registrations found.
ID
Source
Health condition
lower grade gliomas
radiotherapy
hersentumoren
glioom
radiotherapy
cognition
cognitie
neurocognition
neurocognitie
Sponsors and support
Intervention
Outcome measures
Primary outcome
DTI parameters in correlation with cognition
Secondary outcome
not applicable
Background summary
Radiotherapy is ofter part of the treatment for patients with lower grade gliomas. The progosis for these patients is good. That make long term effects of radiotherapy important. Radiotherapy can decrease neurocognitive function which impact both the patients as well as their relatives.
DTI can visualise the microstructure of the white matter of the brain using MRI. We expect to find changes on DTI is correlation with the cognitive function of patients. DTI is expected to be more sensitive compared to standard MRI sequences (T2/FLAIR).
This pilot study aims at demonstrating a correlation between DTI abnormalities and cognition in patients with lower grade gliomas of the brain after radiotherapy.
Study objective
Impaired congition correlates with imaging abnormalities on DTI
Study design
cross-sectional one measurement DTI acquired during normal follow-up MRI
Intervention
MRI DTI
A. Hoorn, van der
PO Box 30 001
Groningen 9700 RB
The Netherlands
+31503616161
a.van.der.hoorn@umcg.nl
A. Hoorn, van der
PO Box 30 001
Groningen 9700 RB
The Netherlands
+31503616161
a.van.der.hoorn@umcg.nl
Inclusion criteria
Patients with histological proven lower grade glioma (WHO II or III) treated and follow-up at the UMCG.
Informed consent
Exclusion criteria
Age <18 years
After radiotherapy new operation or second time radiotherapy
Contraindication for MRI (ferromagnetic material, pregnancy, claustrofobia)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5048 |
| NTR-old | NTR7446 |
| Other | UMCG research register : 201800596 |