No registrations found.
ID
Source
Brief title
Health condition
Innate Immunity
Radio Stereometric Analysis
Aseptic Loosening
Knee Replacement Arthroplasty
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Maximum Total Point Motion at 1 year, measured by RSA;
2. PAM3Cys and LPS-stimulated cytokine profiles.
Secondary outcome
N/A
Background summary
Aseptic loosening is the most common cause of failure of current joint
replacement arthroplasties in the long term (>10 years after index
surgery). Wear particles cause a sterile periprosthetic inflammatory
process, which leads to osteolysis and formation of fibrous tissue.
Pro-inflammatory cytokines play a major role in this process.
Micromotion preceeds aseptic loosening and can be accurately measured by
RSA. RSA measurements can only be performed if tantalum markers are
inserted during surgery.
Innate immunity can be determined at any time, even pre-operatively.
Innate immunity may even be a useful tool in predicting the preoperative
risk of aseptic loosening.
Study objective
What does the non-specific cytokine response contribute to the prediction of prosthesis fixation (expressed in MTPM after 1 year), compared with simple patient characteristics?
Study design
Patients will undergo a single venipuncture, to obtain 32ml of blood.
Intervention
N/A
J.C. Keurentjes
Albinusdreef 2, Room J-09-127
Leiden 2300 RC
The Netherlands
+31 (0)71 526 1566
j.c.keurentjes@lumc.nl
J.C. Keurentjes
Albinusdreef 2, Room J-09-127
Leiden 2300 RC
The Netherlands
+31 (0)71 526 1566
j.c.keurentjes@lumc.nl
Inclusion criteria
1. Patients over 18 years, who underwent elective knee replacement arthroplasty;
2. Patients who are part of an RSA-cohort and whose MTPM at 1 year have been measured.
Exclusion criteria
1. No measurable MTPM at 1 year, or inadequate registration;
2. Tibia component in frontal plane greater than 5 ° varus or valgus 5.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2081 |
| NTR-old | NTR2197 |
| CCMO | NL30892.058.09 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON32587 |