No registrations found.
ID
Source
Brief title
Health condition
Patients with end-stage heart failure
Sponsors and support
Intervention
Outcome measures
Primary outcome
To develop non-invasive selection criteria (using echocardiography) to identify patients with end-stage heart failure who are likely to benefit from biventricular pacing.
Secondary outcome
N/A
Background summary
N/A
Study objective
In patients with end-stage heart failure (NYHA class III or IV, LVEF <35%, QRS duration >120 ms, LBBB), the dyssynchrony of the left ventricle is the most important predictor of clinical benefit.
The dyssynchrony of the left ventricle can be assessed (at any time before implantation) non-invasively by Tissue Doppler Imaging(TDI).
Thus, information on dyssynchrony derived from TDI may predict clinical benefit from biventricular pacing (BVP).
Study design
N/A
Intervention
Patients will undergo BVP implantation based on traditional selection criteria. VO2 max and TDI will be performed before and 3 months after BVP implantation. From these patients the TDI criteria which optimally predict clinical improvement (in VO2 max) will be derived.
Department of Cardiology,
P.O. Box 9600
J.J. Bax
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+31 (0)71 5262020
j.j.bax@lumc.nl
Department of Cardiology,
P.O. Box 9600
J.J. Bax
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+31 (0)71 5262020
j.j.bax@lumc.nl
Inclusion criteria
1. Severe heart failure (NYHA class III or IV);
2. Severely depressed left ventricular ejection fraction (LVEF <35%);
3. QRS exhibiting left bundle branch block configuration with a duration >120 ms.
Exclusion criteria
N/A
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL442 |
| NTR-old | NTR482 |
| Other | : N/A |
| ISRCTN | ISRCTN09353557 |