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ID
Source
Brief title
Health condition
English: Dystonic tremor, Dystonia, Essential tremor, tacs
Dutch: Tremor bij Dystonie, Dystonie, Essentiële tremor, tacs, beven
Sponsors and support
Kapittelweg 29 6525 EN Nijmegen
Intervention
Outcome measures
Primary outcome
1) phase specific tremor power suppression during M1 tacs, in ET vs DT
2) phase specific tremor power suppression during Cerebellar tacs, in ET vs DT
3) Phase specific tremor related cerebral activity during cerebellar tacs, in ET vs DT
Secondary outcome
-Tremor related cerebral activity and connectivity, compared between dystonic and essential tremor.
-GABA concentrations in GPi, cerebellum and primary motor cortex, compared between dystonic and essential tremor.
Background summary
“In this study we will investigate whether frequency and phase specific transcranial alternating current stimulation (TACS) over the primary motor cortex and cerebellum influences tremor in dystonia and essential tremor. Outcome measures are tremor power (based on accelerometry) and tremor related cerebral activity and connectivity (combined TACS-fMRI). In addition, we will study the cerebral mechanisms underlying tremor in both disorders by using combined EMG-fMRI and GABA-MRS.”
Study objective
Reduced tremor power during transcranial alternating current stimulation over primary motor cortex (at tremor frequency and phase-locked to the ongoing tremor).
Study design
Not applicable, 2 visits for each participant, outcome measures divided over the two days.
Intervention
Transcranial alternating current stimulation (tacs) over primary motor cortex and cerebellum at tremor frequency and phase locked to ongoing tremor (as measured with accelerometry).
Stimulation during 20 blocks of 30s, at 18 degree phase difference increments around the phase circle (random ordering, phase difference between ongoing tremor and tacs).
Inclusion criteria
Essential tremor:
-Clinical diagnosis of essential tremor
-Postural tremor of both hands
-Onset of tremor before the age of 65
Dystonic tremor:
-Clinical diagnosis of dystonic tremor
-Primary focal / segmental dystonia
-Presence of postural tremor of at least one arm (which may or may not be the dystonic limb)
Exclusion criteria
-Neurological co-morbidity
-Moderate to severe head tremor (to avoid artifacts caused by extensive head motion during scanning)
-Cognitive dysfunction (clinical diagnosis of mild cognitive impairment or dementia)
-Considerable diagnostic doubt between essential and dystonic tremor (no consensus reached in team meetings neurologists or considerable doubt in medical record).
-Use of anti-tremor medication other than propranolol
-Any contraindications for MRI or transcranial stimulation (e.g. non compatible metal implants, epilepsy, active implants).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6686 |
| NTR-old | NTR6856 |
| Other | NL60335.091.17 : HA2016-02-01 |