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ID
Source
Brief title
Health condition
engels: migraine, headache, eyeblink, cerebellum, sway-test
nederlands: migraine, oogknipper, cerebellum, sway-test
Sponsors and support
Intervention
Outcome measures
Primary outcome
The conditioning as measured with eyeblink between migrainepatients and controls.
Secondary outcome
1. The sensitivity of trigeminus system by migrainepatients compared with controls.
Do the results of the disturbed conditioned corresponds to a coordinationdisorder measured by the sway-test?;
2. The relations between the contols, the migrainepatients and the patients with a degenerative disease.
Background summary
Earlier examinations possibly shows small damage of the cerebellum in patients with migraine, especially in patients with aura. These defects are structural as well as functional. It is also shown that conditioning largely takes place in the cerebellum. The eye-blinker is a valid method to measure conditioning. The Sway-test is a good methode to measure the coordination and to detect minimal movements.
This study will examine the difference in conditioning between patients with migraine en healthy volunteers.
Study objective
Migraine patients, compared with healthy volunteers, have more subclinical cerebellar dysfunctions, measured by the eye-blinker.
Study design
N/A
Intervention
The difference in the conditioning, between migraineurs and healthy volunteers,
is measured by using the eyeblinker. The technique is called the chip-MDMT
(Magnetic Distant Measurement Technique). A magnet will be placed on the right eyelid. A sensor will be placed below the right eye. So the length, the power and the time of each blink is measured. The test will consist of 8 trials of 6 minutes. A conditioned respons will be generated by using airpuffs and tones.
P.O. Box 9600
W. Brekelmans
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+ 31 71-5261730
w.brekelmans@umail.leidenuniv.nl
P.O. Box 9600
W. Brekelmans
Albinusdreef 2
Leiden 2300 RC
The Netherlands
+ 31 71-5261730
w.brekelmans@umail.leidenuniv.nl
Inclusion criteria
1. Patients with migraine and aura with minimal 6 attacks a year (2 with aura);
2. Healthy volunteers without migraine;
3. Patients with a cerebellar degenerative diseases.
Exclusion criteria
For the migrainepatients and healthy controls:
1. Neurologic diseases in which the function of cerebellum is disturbed;
2. The use of medicines/drugs which have influence on the coordination 24 hours before taking part of this examination.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL914 |
| NTR-old | NTR938 |
| Other | : N/A |
| ISRCTN | ISRCTN94004433 |