- To determine the numbers of dividing cells focused whether hyperproliferation or hypoplasia can be determined.- To determine whether the progenotor or stem cell is different affected.- Can intrinsic defects of the CD34+ cells be demonstrated that…
ID
Source
Brief title
Condition
- Haematopoietic neoplasms (excl leukaemias and lymphomas)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- In-vitro culture assay of CD34+ cells.
- Phenotypic characterization of the CD34+ cell population.
- Micro-array analysis of CD34+ cells.
- FLT-PET
Secondary outcome
Not applicable
Background summary
A high number of patients have a persistent pancytopenia during a number of
months after the transplantation. The cause of this finding has not been
elucidated but might be caused by an inadequate homing of the stem cells during
the transplantation procedure, related to the chemotherapy applied before the
transplantation on due to a ongoing stress-response which affects strongly the
properties of the stemcell compartment.
Study objective
- To determine the numbers of dividing cells focused whether hyperproliferation
or hypoplasia can be determined.
- To determine whether the progenotor or stem cell is different affected.
- Can intrinsic defects of the CD34+ cells be demonstrated that correlate with
the observed abnormalities.
Study design
On basis of these findings in-vitro parameters of the bone marrow compartment
will be analyzed. In addition the total bone marrow compartment will be
visualized by FLT-PET.
Study burden and risks
- Local pain due to bone marrow aspirate.
- Time related to FLT-PET and intra venous injection of the tracer.
Hanzeplein 1
9713 GZ Groningen
NL
Hanzeplein 1
9713 GZ Groningen
NL
Listed location countries
Age
Inclusion criteria
ASCT
Exclusion criteria
Persistent disease activity in the bone marrow.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL13858.042.06 |