The obtained FOT parameters can distinguish the group of COPD patients with expiratory flow limitation in body plethysmography from the patients without expiratory flow limitation in body plethysmography.
ID
Source
Brief title
Condition
- Respiratory disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Xrs-8 (cmH20.s/L) (shorthand notation for the most negative value of Xrs during
expiration at 8 Hz)
Open or closed loop in pressure-volume loop measured by the body
plethysmography
Secondary outcome
Spirometry: FEV1 (L), FVC (L), IC (L), VC max (L),
CO-diffusion: TLCOSB, kCO
Body plethysmography: RV (L) TLC (L)
Forced oscillation technique:
Xrs-12,16,20,24 (cmH20.s/L)
Rrs-8,12,16,20,24 (cmH20.s/L)
Phase-8,12,16,20,24 (degrees)
Amplitude-8,12,16,20,24 (cmH20.s/L)
Other study parameters
Anthropometrical data
Background summary
The forced oscillation technique (FOT) is a non-invasive method to measure the
mechanical properties of the respiratory system. Small amplitude pressure
oscillations are applied to the mouth during apnea, but can also be
superimposed on the normal breathing pattern. In COPD, expiratory flow
limitation (EFL) is a major determinant of hyperinflation and exercise
limitation. In this study we want to compare FOT using linear regression in the
time frequency domain with the standard lungfuntion test for detecting
expiratory flow limitation, the body plethysmography.
FOT has the advantage over body plethysmography that it can detect
within-breath changes in flow limitation and follow the changes during multiple
breaths.
We hypothesize that the obtained FOT parameters can distinguish the group with
expiratory flow limitation in body plethysmography from the patients without
expiratory flow limitation in body plethysmography. The goal for the future is
to apply FOT in different lung function tests, especially during exercise
testing, to be able to get more information on expiratory flow limitation
during exercise in COPD patients.
Study objective
The obtained FOT parameters can distinguish the group of COPD patients with
expiratory flow limitation in body plethysmography from the patients without
expiratory flow limitation in body plethysmography.
Study design
Observational research without invasive measurements
Study burden and risks
Spirometry, body plethysmography and CO-diffusion are standard diagnostic tests
performed in the pulmonary function test department. No extra risk are foreseen
in this study. Salbutamol can give a tachycardia based on its pharmacological
characteristics. Using salbutamol can give this adverse event which is seldom a
serious adverse event.
Forced oscillation technique is not (yet) a standard diagnostic test. It is a
non-invasive test. No adverse events are foreseen due to this test.
Wilhelminalaan 12
1815 JD Alkmaar
Nederland
Wilhelminalaan 12
1815 JD Alkmaar
Nederland
Listed location countries
Age
Inclusion criteria
All patients should meet the standard diagnostic criteria for COPD and they are current or ex-smokers. The subjects must have stable disease at the time of the inclusion, which means that they cannot have an exacerbation of the COPD during the 4 weeks previous to the inclusion
Exclusion criteria
History of exacerbation of COPD in the preceding month
Upper airway obstruction
Allergic Asthma
OSAS
Extreme obesity (BMI>35)
Pulmonary disease other than COPD
Clinically manifest cardiac disease (for example clinically relevant congestive heart failure, unstable angina pectoris)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL13873.094.06 |