To investigate the gene and protein expression of neonates suffering from CoNS late-onset sepsis.
ID
Source
Brief title
Condition
- Bacterial infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Difference in genomic transcription profiles and protein profiles between
patients and controls.
Secondary outcome
To gain insight in similarities and differences in gene expression profiles
between neonates suffering from CoNS sepsis and children suffering from
meningococcal sepsis.
Background summary
Nosocomial infections caused by coagulase-negative staphylococci occur
frequently in neonates, because of an immature immune system and invasive
procedures. Studying the immune system during infection may lead to better
understanding of the pathophysiology and consequently to adequate (future)
prevention measures.
Study objective
To investigate the gene and protein expression of neonates suffering from CoNS
late-onset sepsis.
Study design
Monocenter, non-therapeutic, observational study.
Study burden and risks
A maximum of three blood samples of 1 ml each will be drawn from the study
subject. Blood will be drawn from existing arterial lines if present, or
combined with medically necessary blood takings. Patients will not directly
benefit from this study, although patients in the future might.
Dr. Molewaterplein 50
3015 GE Rotterdam
Nederland
Dr. Molewaterplein 50
3015 GE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Admission on neonatal intensive care unit
Clinical signs of late-onset sepsis
Weight at least 750 g
Exclusion criteria
Birth weight < 750 g
No informed consent
Positive blood culture for bacteria other than coagulase-negative staphylococci
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL13424.078.06 |