to determine the correlation of fetal hyperinsulinemia (measured by urine c-peptide) and maternal indicators of glucose-regulation with neonatal birth weight and postpartum glucose concentration of macrosomic infants of non-diabetic mothers
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
- Pregnancy, labour, delivery and postpartum conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
birth weight, urine C-peptide, glucose concentration, fructosamine, HbA1c
Secondary outcome
not applicable
Background summary
LGA infants are at greater risk for developing postnatal hypoglycemia. Fetal
growth during pregnancy is influenced by many different factors, such as
maternal hyperglycemia. In respons to this maternal hyperglycemia, fetal
hyperinsulinemia develops. Previous studies have shown that this
hyperinsulinemia plays a role in fetal macrosomia, as insulin is an important
growthfactor. C-peptide is secreted by the pancreas in equimolar quantaties to
insulin, as both derive from pro-insulin.Therefor, the concentration of
C-peptide can be used as an indicator of beta cell secretion of insulin.
C-peptide is excreted in urine. Previous studies have shown a positive
correlation between C-peptide in cord blood and birth weight, also in children
born from non-diabetic mothers. We want to determine if C-peptide concentration
in urine is correlated to birthweight and postpartum hypoglycemia of LGA
infants of non-diabetic mothers. Furthermore we want to investigate if there is
a relation between the neonatal C-peptide and glucose concentration postpartum
and the maternal concentration of fructosamine and HbA1c, as both are
indicators of glucoseregulation
Study objective
to determine the correlation of fetal hyperinsulinemia (measured by urine
c-peptide) and maternal indicators of glucose-regulation with neonatal birth
weight and postpartum glucose concentration of macrosomic infants of
non-diabetic mothers
Study design
This is a monocentre prospective study which will take place in Medisch
Spectrum Twente. Urine C-peptide and postpartum glucose concentrations will be
measured of macrosomic infants of non-diabetic mothers. Measurement of glucose
concentration is standard in these infants. Futhermore, maternal concentrations
of fructosamine and HbA1c will be determined.
Statistical analysis will be used to show if neonatal urine c-peptide and
maternal fructosamine/HbA1c concentrations correlates to birthweight and
postpartum glucose concentrations of the infant.
Study burden and risks
The risks of urine sampling and blood withdrawl are negligible.
ariensplein 1
postbus 50000, 7500 KA enschede
Nederland
ariensplein 1
postbus 50000, 7500 KA enschede
Nederland
Listed location countries
Age
Inclusion criteria
large-for-gestational-age
Exclusion criteria
diabetic mother
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL13770.044.06 |