To investigate peripheral circulation in the hyperdynamic circulation of cirrhotic patients and its correlation with the Child-Pugh score.
ID
Source
Brief title
Condition
- Other condition
- Hepatic and hepatobiliary disorders
Synonym
Health condition
microcirculation
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Vascular reactivity as measured by changes in PFI and NIRS in a human reactive
hyperaemia model.
Secondary outcome
Peripheral perfusion as measured by PFI and OPS; peripheral tissue oxygenation
as measured by NIRS.
Background summary
Liver cirrhosis is associated with a hyperdynamic circulation characterized by
vasodilation, low arterial pressure and high cardiac output. The vasodilation
is most evident in the splanchnic circulation. Although peripheral vasodilation
has been associated to the cirrhosis-induced hyperdynamic circulation, its role
in these patients is still subject of controversy. More research is needed to
define if the peripheral vascular tone in cirrhosis is constricted or dilated.
Also, impaired vascular reactivity has been associated with the severity of
cirrhosis. Peripheral circulation and vascular reactivity can be assessed using
noninvasive techniques such as peripheral perfusion index (PFI), near infrared
spectroscopy (NIRS) and orthogonal polarization spectral (OPS). This has never
been done in cirrhotic patients.
Study objective
To investigate peripheral circulation in the hyperdynamic circulation of
cirrhotic patients and its correlation with the Child-Pugh score.
Study design
Prospective and observational study.
Study burden and risks
This research entails negligible risks and minimal discomfort.
Dr. Molewaterplein
3015-GD
Nederland
Dr. Molewaterplein
3015-GD
Nederland
Listed location countries
Age
Inclusion criteria
Cirrhosis Child-Pugh B and C.
Exclusion criteria
Patients with one of the following non-cirrhotic diseases: arterial hypertension, diabetes mellitus, and peripheral vascular disease.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL14621.078.06 |