To compare respiratory waveforms generated using reflective markers located on the upper abdominal wall (the currently used Varian RPM system) with either magnetic sensors, belt sensors or both placed on the chest wall and/or upper abdomen. The…
ID
Source
Brief title
Condition
- Malignant and unspecified neoplasms gastrointestinal NEC
- Respiratory tract neoplasms
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To compare respiratory waveforms generated using the standard method with two
new measurement systems. The generated waveforms will also be correlated with
tumour position and movement.
Secondary outcome
1. Determine if gating parameters derived from either magnetic or belt sensors
can substitute for data from the presently used RPM system.
2. Develop improved strategies for delivering respiration-gated radiotherapy
(RGRT) using multiple respiratory signals
Background summary
In 4D radiotherapy, patients undergo planning and/or delivery based upon
respiratory waveforms. The currently used technology to measure respiratory
waveforms (the RPM system) will be incompatible with the future PET-CT,
implying that at least two different respiration monitoring systems will be
used for 4D treatments at VUmc. These systems must be mutually compatible in
order to insure accuracy of treatment delivery.
Study objective
To compare respiratory waveforms generated using reflective markers located on
the upper abdominal wall (the currently used Varian RPM system) with either
magnetic sensors, belt sensors or both placed on the chest wall and/or upper
abdomen. The generated waveforms will be correlated with tumour position and
movement.
Study design
Thirty patients will undergo standard 4DCT planning scans using both devices
(belt and magnetic sensors) in addition to the standard RPM device. If a
patient cannot tolerate the use of both systems, additional patients will be
recruited in order to generate full numbers.
When patients undergo subsequent radiotherapy, monitoring of respiratory
waveform will be performed using at least 1 of the 2 systems (belt and magnetic
sensors) during treatment delivery. A minimum of 30 patients will be included.
Total = 30-50 patients
Study burden and risks
None, except the relativelty short time needed to apply the measurement
devices. No extra CT-scans will be performed, respiratory waveforms will be
collected during the standard radiotherapy planning 4DCT scan. The studies are
exploratory and no intervention is planned on the basis of the additional
recordings. All measurement methods are non-invasive.
De Boelelaan 1117, Postbus 7057
1007 MB Amsterdam
Nederland
De Boelelaan 1117, Postbus 7057
1007 MB Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Patients undergoing a respiration correlated (4D) CT scan as part of their standard radiotherapy treatment preparation.
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL14350.029.06 |