In the proposed experiment we expect to find a similar functional segregation within prefrontal and premotor cortical regions when a free choice option is introduced.
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Local increases in neuronal activation will inferred from the local BOLD
responses. Significance of such responses will be tested by SPM (ANOVA).
Secondary outcome
nvt
Background summary
The proposed functional MRI (fMRI) experiment aims to investigate the
differences in the cerebral organization of actions that are internally
specified (free choice) and externally specified (fixed instruction). In our
previous neuro-imaging experiment both parietal and hemispherical segregation
was found when contrasting ego- and allocentric spatial reference frames in
visuomotor reaching.
Study objective
In the proposed experiment we expect to find a similar functional segregation
within prefrontal and premotor cortical regions when a free choice option is
introduced.
Study design
The experiment consists of a visuomotor task with auditory instructions. During
scanning, subjects have to push a button on a response box with a right hand
finger. This action is observed by mirror The task consists of 4 conditions in
which (1) one of many fingers has to push the same button, (2) the index finger
has to push various buttons. Both tasks can be performed in response to a fixed
instruction (3), or with allowing free choices (4). By distinguishing the
actions specified by the spatial reference frames (button/finger), as well as
those specified by free choice or fixed response, we are able to differentiate
between the cortical processing of internal and external specified actions in
relation to spatial reference frames. Differences in task-related neuronal
activations will be analysed with voxel-based statistics (SPM).
Study burden and risks
nvt.
hanzeplein 1 (postbus 30.001)
9700 RB Groningen
Nederland
hanzeplein 1 (postbus 30.001)
9700 RB Groningen
Nederland
Listed location countries
Age
Inclusion criteria
healthy right-handed subjects, 18-65 y
Exclusion criteria
neurological or ophtalolmogical disease,
pregnancy, claustrofobia,
carrier of ferromagnetic material,
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15435.042.06 |