Identification of genetic risk factors for development of type 2 diabetes, diabetes related diseases and complications. Furthermore the examination of the relationship between genetic variation, biochemical factors, environmental factors (obesity…
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
- Diabetic complications
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The construction of a bio-databank containing genetic profiles as well as
biochemical and clinical characteristics of the patients will be the endpoint.
This bio-databank and the occurrence of diabetes complications or diabetes
related diseases will be used to calculate the risk of developing type 2
diabetes.
Secondary outcome
not applicable
Background summary
Several genetic factors of type 2 diabetes mellitus have been identified during
the past years. However, progress has been slow. Furthermore the effect size of
the known genetic susceptibility factors has shown to be relatively low. This
suggests that only a combination of several genetic risk factors in association
with a detrimental life style will eventually lead to chronic hyperglycaemia,
which is the general hallmark of type 2 diabetes mellitus. The low impact of
individual genetic defects implicates that only sufficiently powered studies
(i.e. with large sample sizes) will be able to detect associations between a
gene and the disease. Currently even less is known about the impact of these
genetic factors on the development of diabetic complications, mainly because
the current studies are underpowered due to insufficient sample sizes.
Increased knowledge about the pathogenesis of the disease and disease-related
complications might provide better prevention and treatment options for those
at risk. Moreover, it might enable us to halt the rapidly growing number of
patients worldwide.
Study objective
Identification of genetic risk factors for development of type 2 diabetes,
diabetes related diseases and complications. Furthermore the examination of the
relationship between genetic variation, biochemical factors, environmental
factors (obesity etc) and the development of type 2 diabetes, diabetes related
diseases and complications.
Study design
Observational cohort study
Study burden and risks
Informed consent to search medical records and a donation of four blood samples
(40 ml) will be asked of the participants. Because this will be done during one
of the regular visits, the risk as well as the burden for the participants is
negligible. Part of the donated blood samples will be stored for future
research in a Diabetes Bio-databank. Benefit for the participants will be the
identification of novel risk factors for type 2 diabetes which may facilitate
the development of better prevention and treatment options for those at risk.
van der Boechorststraat 7
1081 BT Amsterdam
NL
van der Boechorststraat 7
1081 BT Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Having type 2 diabetes and participating in the diabetes care system West-Friesland.
Exclusion criteria
No diabetes type 2 or no participant of the Diabetes care system West-Friesland.
Type 1 diabetes or requiring insulin therapy within one year after diagnosis.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL14692.029.07 |