The aim of this experimental study is to find out whether children and young adults with the DS have an altered pain sensitivity in comparison with children and young adults without cognitive impairement.
ID
Source
Brief title
Condition
- Other condition
- Structural brain disorders
Synonym
Health condition
verstandelijk handicap
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Detection threshold warm, pain threshold heat pain, pain report to different
heat and heat (pain) stimuli.
Secondary outcome
none
Background summary
Children with Down syndrome (DS), do show pain behavior. However, their
responses to pain are less vigoruous than in children without mental
retardation. Because of this, it is generally believed that these children are
less sensitive to pain. Evidence to accept this assumption, however, is
lacking. Perhaps these children are more sensitive to pain, but because of
their handicap they do not have the ability to respond quickly or more
vigorously. Recently, however, it was shown that adults with the Down syndrome
had lower pain thresholds than adults without cognitive impairment, suggesting
greater pain sensitivity. Whether this finding can be contributed to the Down
syndrome or whether this is due to a lower cognitive functioning in the Down
people remains unclear.
Study objective
The aim of this experimental study is to find out whether children and young
adults with the DS have an altered pain sensitivity in comparison with children
and young adults without cognitive impairement.
Study design
Experimental study using balanced groups
Intervention
All study subjects will undergo thermal (pain) stimuli.
Study burden and risks
no risks
Postbus 2060
3000CB Rotterdam
Nederland
Postbus 2060
3000CB Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Index group: Trisomy 21, (biological age 10-12 and 20-22 year-old). Both groups have a social and communicative adaptation behaviour corresponding with that of children without CI of >=7 years, i.e. total score on the Vineland-Z social domain >=97 and a total score on the Vineland-Z communication domain >=93
Reference subjects: children with a biological age of 7-12 years and young adults with a biological age of 20-22 years.
Exclusion criteria
Index group: not able to tell what pain is and when they suffered pain, not responsible to reproduce the instructions given for testing, any record of behavioural or language problems, or use of anti-epileptics, anti-depressives, or spasmolytics.
Reference groups: mental handicap, or use of anti-epileptics, anti-depressives, or spasmolytics.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL11943.000.06 |