To determine the quantitative distal femoral bone resorption from the expected stress shielding effect of the femoral component in patellofemoral arthroplasty.
ID
Source
Brief title
Condition
- Joint disorders
- Bone and joint therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
BMD (g/cm2) of the periprosthetic distal femur and contralateral (non-operated)
knee before patellofemoral arthroplasty, directly after, and 12 months after
arthroplasty.
Secondary outcome
Not applicable.
Background summary
The bone mineral density (BMD) of the distal femur decreases by 20-40% within
one year after total knee arthroplasty (TKA) as a result of the stress
shielding effect of the femoral component. Although the femoral component in
patellofemoral arthroplasty is smaller than in TKA, patellofemoral joint forces
are more evenly redistributed to the femoral condyles. This could lead to bone
remodelling with decreased BMD behind the anterior flange of the femoral
component.
The clinical survival of joint arthroplasties is related to the quality of the
surrounding bone environment. Furthermore, in total knee arthoplasties, bone
loss in the distal anterior femur may lead to supracondylar fractures,
loosening of the implant, and may induce difficulties during revision
arthroplasty.
Since patellofemoral arthroplasty is typically used in younger patients,
revision to total knee arthroplasty will eventually be necessary in a relative
large proportion of patients. The results of such a revision may be compromised
by loss of bone stock.
To date, no clinical studies address the possible loss of distal femoral bone
stock resulting from significant stress shielding with a patellofemoral
prosthesis.
Study objective
To determine the quantitative distal femoral bone resorption from the expected
stress shielding effect of the femoral component in patellofemoral
arthroplasty.
Study design
Invasive observational, without intervention
Study burden and risks
A low radiation dose is associated with DEXA.
Postbus 5001
7400 GC Deventer
NL
Postbus 5001
7400 GC Deventer
NL
Listed location countries
Age
Inclusion criteria
Not applicable
Exclusion criteria
Patients with rheumatic, renal, hepatic or gastrointestinal disease, and patients using medication that interferes with mineral metabolism (i.e. treatment for osteoporosis or long-term steroid therapy).
Previous total knee arthroplasty or patellofemoral arthroplasty of the contralateral knee.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL16145.075.07 |