To identify morphological and molecular characterisations of resected carotid plaques. And to determine biomarkers in serum. The emphasis will lie on inflammatory biomarkers such as Cathepsines and matrix metalloproteinases. Also it will be examined…
ID
Source
Brief title
Condition
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Endpoints will be:
- the find of biomarkers where symptomatic patients are compared with
asymptomatic patients
- the find of certain proteins at proteomics (or hedgehog signals) which can be
correlated to both the presence of the plaque, and (preoperative) symptoms of
the patient.
- showing a detectable signal at fluorescence, a relation will be sought
between the intensity of the signal and the vulnerability of the plaque
(related to previously detected biomarkers and patient symptoms).
Secondary outcome
nvt
Background summary
Currently, the indication for a carotid endarterectomy is set on the grade of
stenosis. The morphology of the carotid plaque plays no role in the indication
for surgery. It is likely that a vulnerable plaque will sooner become
symptomatic than a stable plaque, independent of grade of stenosis. With
conventional imaging techniques, plaque morphology is not adequate to determine.
Study objective
To identify morphological and molecular characterisations of resected carotid
plaques. And to determine biomarkers in serum. The emphasis will lie on
inflammatory biomarkers such as Cathepsines and matrix metalloproteinases. Also
it will be examined to what extent fluorescence indicators are detectable in
the resected plaques.
Study design
Pre- and postoperative, blood will be drawn from the patient. The carotisplaque
will surgically be removed. The material will be examined on biomarkers, among
other things cathepsines and matrix metalloproteinases. Also, with bio-optical
agents, fluorescence will be determined in the resected carotid plaques.
Study burden and risks
The carotid plaque will be resected surgically in the usual manner. Blood will
be drawn twice, by venous puncture.
Hanzeplein 1
Postbus 30 001, 9700 RB, Groningen
NL
Hanzeplein 1
Postbus 30 001, 9700 RB, Groningen
NL
Listed location countries
Age
Inclusion criteria
asymptomatic stenosis of the internal carotid artery, stenosis >80%
symptomatic stenosis of the internal carotid artery, stenosis >70%
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17259.042.07 |