To obtain skin biopsies of healthy volunteers for scientific research.
ID
Source
Brief title
Condition
- Neurological disorders congenital
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Not applicable.
Secondary outcome
Not applicable.
Background summary
Fibroblasts are an excellent model system for the study of metabolic disease.
Besides patient cell lines, fibroblasts from healthy volunteers are also
necessary to obtain reference values for the measured parameters. Cells can be
cultured for only a few months before they lose the ability to divide
(non-immortalized cells). Therefore a fresh supply of biopsies is necessary
from time to time. Healthy individuals rarely undergo skin biopsies, and the
consequence is that these cells are relatively scarce. Using leftover tissue
(from surgery or cadavers) is not a feasible option, since these cells are
often of poor quality (not immediately preserved in culture medium,
contaminated with micro-organisms). The goal of this project is to obtain skin
biopsies from healthy volunteers for the scientific study of metabolic disease.
Study objective
To obtain skin biopsies of healthy volunteers for scientific research.
Study design
Healthy volunteers undergo a skin biopsy in an outpatient clinic setting.
Study burden and risks
Participants undergo one skin biopsy, which is sometimes considered painful.
There is a minimal risk of wound infection. A scar may be visible after wound
healing.
Meibergdreef 9
1100DD Amsterdam
Nederland
Meibergdreef 9
1100DD Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Healthy male or female over 18 years of age
Exclusion criteria
Disorders of the coagulation system making a skin biopsy unsafe
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18194.018.07 |