Improve the insight in the aetiology of CAP by season and by population in the Netherlands by the use of an extensive combination of microbiological techniques.Moreover this study will provide an unique sample from a well defined patient population…
ID
Source
Brief title
Condition
- Hepatobiliary neoplasms malignant and unspecified
- Respiratory tract infections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Aetiological agents of CAP will be identified using an extensive combination of
microbiological techniques (including culture, PCR, serology and rapid antigen
detection).
Secondary outcome
Other parameters include specific host factors like age and co morbidity and
the severity of CAP. These will be studied in relation with the detected
aetiological pathogens.
Background summary
Community Acquired Pneumonia (CAP) is defined as an acute symptomatic infection
of the lower respiratory tract which develops outside the hospital or nursing
home. CAP can be a life threatening disease especially in the elderly and in
the presence of co morbidity. In recent years CAP has an incidence of 5-10
cases per 1000 persons a year in the Netherlands and is a major cause of
morbidity, hospitalization and mortality. CAP can be caused by many different
pathogens. However little is known about the exact aetiology of CAP in the
Netherlands as this requires extensive microbiological testing which is only
performed on a limited scale. Furthermore, studies already performed show
strong variations in the incidences of different pathogens.
Study objective
Improve the insight in the aetiology of CAP by season and by population in the
Netherlands by the use of an extensive combination of microbiological
techniques.
Moreover this study will provide an unique sample from a well defined patient
population, which can supply essential reference information when in the future
(new) pathogens will be identified as a potential cause of CAP. Secondary
objectives include prospective validation of new diagnostic tests for certain
pathogens as well as comparison of accepted biomarkers of infection with
potentially new biomarkers.
Study design
Prospective observational study.
Study burden and risks
For all patients participating in the study, routine sampling will involve
collection of sputum and blood to guide therapeutic decisions as usual.
Furthermore, additional blood, serum, urine, nose swab and throat swab will be
collected. Urine antigen tests for S. pneumoniae and L. pneumophila, both
important CAP related pathogens, will be performed. These tests can be done
easily and rapidly, but are not routinely used at JBZ yet. Because the test
results will be available in a clinical relevant time period, this might
positively influence treatment choices from a broad spectrum antibiotic
treatment to a pathogen directed antibiotic treatment. The other additional
microbiological investigations are not expected to have a direct benefit for
the patient as the test results will not be available in a clinical relevant
time. However, better understanding of the pathogenesis of CAP is of public
health importance since it might influence future treatment.
postbus 1
3720 BA BILTHOVEN
Nederland
postbus 1
3720 BA BILTHOVEN
Nederland
Listed location countries
Age
Inclusion criteria
Age >= 18 years
Visiting emergency room of JBZ with (suspicion) of CAP according to the guidelines of the Dutch Working Party on Antibiotic Policy (SWAB,2005)
Written informed consent
Exclusion criteria
Age < 18 years
Patients transferred from another hospital
Patients residing in a nursing home
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18156.028.07 |