1.To describe whether vascular lesions are more frequent in elderly heart failure patients compared to elderly patients with cardiovascular disease but no heart failure.2.To describe the association between these vascular lesions and executive…
ID
Source
Brief title
Condition
- Heart failures
- Central nervous system vascular disorders
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Amount of cebrovasculair lesions, mainly consisting of white matter lesions
which will be semiquantitatively measured by volumetry
Secondary outcome
(lacunar) infarctions
atrophy
Background summary
Due to the aging population heart failure is becoming an increasing problem.
Heart failure is associated with cognitive deterioration. Cognitive disorders
are prognostically significant in chronic heart failure patients. The specific
neuropsychological profile in heart failure patients is still not clear because
most clinical neuropsychological test mainly measured memory, language,
perceptual abilities and not executive functioning. It is known that executive
dysfunction is an important determinant of functional status. Neuroimaging of
the brain has hardly been performed in elderly heart failure patients. There is
little evidence that heart failure is associated with white matter lesions
(WML's). It is suggested that these WMLs result from chronic ischemia due to
hypoperfusion and disturbance of cerebral blood flow. This reduced cerebal
blood flow is probably the main pathophysiological mechanism in the development
of cognitive impairment in heart failure.
Study objective
1.To describe whether vascular lesions are more frequent in elderly heart
failure patients compared to elderly patients with cardiovascular disease but
no heart failure.
2.To describe the association between these vascular lesions and executive
dysfunction
Study design
Pilot study, descriptive and explorative. .Substudy of AGED-HF study
Magnetic Resonance imaging of cerebrum and echo duplex of the carotid arteries
will be performed in participants of the AGED-HF study.
Study burden and risks
Participants have to visit the hospital once for MRI scan and echo duplex of
the carotid arteries. This will take about 1 hour. There are acccording to us
no risks associated with partipation.
postbus 9101
6500 HB Nijmegen
Nederland
postbus 9101
6500 HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
Aged 70 years and over, Able to visit the Deventer Hospital, documented diagnosis of heart failure, Full comprehension of the Dutch language, informed consent
Exclusion criteria
Metal pieces anywhere in the body, Defribillator, Pacemaker, Metal pins in the cerebrovascular circulation, Neurostimulator in the spinal canal, (Blood vessel ) Stent in the past 6 weeks, Ossicle prothesis, bladderstimulator, insulinpump
Claustrophobia, Acute disease or acute care needed, Dialysis, Life expectancy of less than 3 months, Medically unstable or too sick to be referred to the heart failure outpatient clinic during the inclusion period, Patients with a documented diagnosis of dementia, Nursing home patients
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL19242.091.07 |