To neurophysiologically characterize the sensory and nociceptive system in stroke patients with (CVA+) and without (CVA-) shoulder pain versus healthy controls.
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Clinical sensory function, sensory thresholds to electrical and mechanical QST
before and after a cold pressor test, evoked potentials from cutaneous
electrical stimulation.
Secondary outcome
x
Background summary
Shoulder pain is frequently observed in stroke patients and in some cases
difficult to treat. Better prevention in the acute phase and optimization of
treatment in the chronic phase after stroke may be accomplished when more is
known about neurophysiologic mechanisms underlying the development and
maintenance of shoulder pain following stroke.
Study objective
To neurophysiologically characterize the sensory and nociceptive system in
stroke patients with (CVA+) and without (CVA-) shoulder pain versus healthy
controls.
Study design
In this cross-sectional experiment, clinical en quantitative measures will be
used in 2 seperate sessions. In Session 1, sensibility is tested with standard
clinical neurological tests (touch, temperature and sharpness) and sensory
thresholds are determined using electrical and mechanical quantitative sensory
testing (QST) before and after a cold pressor test. In Session 2 the evoked
potentials will be assessed in 25 subjects from each group using
electro-encephalography (EEG).
Study burden and risks
The burden of participation is low. Both sessions take a maximum of 1.5 hours
each and the experiments are non-invasive. There are no physical and mental
risks of participation.
Postbus 217
7500 AE
Nederland
Postbus 217
7500 AE
Nederland
Listed location countries
Age
Inclusion criteria
General: 18 years and older, legally competent, able to communicate, cognitively competent, informed consent. Stroke patients: unilateral brain infarct middle cerebral artery, at least 6 months post-stroke. Stroke patients with shoulder pain: chronic shoulder pain (at least 3 months)
Exclusion criteria
General: pregnancy, diabetes, MS, HIV/AIDS, not able to deal with used research methods, no compliance of instructions. Stroke patients: Shoulder pain before stroke, non-stroke related peripheral nerve damage. Stroke patients with shoulder pain: pain other than shoulder, non-stroke related shoulder pain. Stroke without pain and healthy controls: pain (acute or chronic) at time of experiment. Healthy controls: use of psychotropic medication or analgetics, peripheral nerve damage.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17316.080.07 |