-Identify the neural correlates of enhanced formation of emotional memory, and parse the role of adrenal stress hormones in this process.-Identify the neural correlates of enhanced consolidation of emotional memory and parse the role of adrenal…
ID
Source
Brief title
Condition
- Anxiety disorders and symptoms
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Functional MRI, memory performance, salivary levels of cortisol and alpha
amylase, self-report questionnaires, and polysomnography (in one trial).
Secondary outcome
n/a
Background summary
During stressful experiences, the synthesis of the hormones adrenalin and
cortisol in the adrenal cortex increases. These hormones influence memory for
such experiences. This research protocol describes four trials in which the
brain mechanisms underlying the formation, consolidation, and re-consolidation
of such experiences, and the role of stress-hormones in this process, are
investigated. Translating and verifying animal models of these processes to
human research is an essential step in the development of neurobiological
models of the etiology of stress related diseases such as posttraumatic stress
syndrome and depression, and may yield new treatment options in the future.
Study objective
-Identify the neural correlates of enhanced formation of emotional memory, and
parse the role of adrenal stress hormones in this process.
-Identify the neural correlates of enhanced consolidation of emotional memory
and parse the role of adrenal stress hormones in this process.
-Specify the timing dependency of effects of adrenal stress hormones on memory
formation.
-Identify the neural correlates of reconsolidation of emotional memory role and
parse the role of adrenal stress hormones in this process.
Study design
Participants will be tested within one out of four separate trials in a placebo
controlled crossover design involving administration of a beta-blocker
(propranolol), a glucocorticoid synthesis blocker (metyrapone), or
hydrocortisone. Brain activity will be mapped using functional Magnetic
Resonance Imaging.
Intervention
Depending on the trial in which participants are classified, they will receive
the following oral administrations: 40 mg propranolol and 2 * 750 mg
metyrapone, or 2*750 mg metyrapone and 2 * 40 mg propranolol, or 2 * 20 mg
hydrocortisone, or 1 * 40 mg propranolol.
Study burden and risks
Participation in this research is without health risks. The burden on
participants consists of time investment (max. 36 hours over multiple sessions)
and several possibly uncomfortable aspects of the investigation, such as
personal questionnaires, blood sampling, ECG, MRI-scans, restrictions in food
intake and alcohol and recreational drug use, and exposure to aversive visual
material.
Kapittelweg 29
6525 EN Nijmegen
NL
Kapittelweg 29
6525 EN Nijmegen
NL
Listed location countries
Age
Inclusion criteria
• Healthy male volunteers between 18 and 45 years of age.
• Predominant right-handedness.
• Body mass index between 18.5 and 30
Exclusion criteria
• Metal objects in or around the body.
• Claustrophobia.
• History of psychiatric treatment or current psychiatric treatment.
• History of neurological treatment or current neurological treatment.
• History of endocrine treatment or current endocrine treatment.
• History of heart related disease
• Regular use of corticosteroids.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL16379.091.07 |