The purpose of this study is to assess the reproducibility of ASL perfusion measurement in the brain.
ID
Source
Brief title
Condition
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cerebral blood flow (100 ml/min/100gr)
Secondary outcome
none
Background summary
The purpose of this study is to assess the reproducibility of ASL perfusion
measurement in the brain. ASL is attractive for especially longitudinal studies
of cerebral blood flow, partly because ASL is an entirely non-invasive
technique that does not involve exposure to ionizing radiation or radioactive
isotopes. However, in order to plan such studies, whether as a single center or
multicenter trial, the error of the measurement itself as well as the natural
fluctuations of cerebral blood flow (CBF) needs to be taken into account when
planning patient population size for a give study.
Study objective
The purpose of this study is to assess the reproducibility of ASL perfusion
measurement in the brain.
Study design
Multicenter trial. A total of 10 volunteers will be scanned each two times , at
a minimum of 1 week interval and maximum of one month to measure brain
perfusion. A total of 30 sites will participate in this multicenter trial,
producing a total of 300 subjects.
Study burden and risks
There are no risks. The burden consists of two times a MRI scan (30 minutes).
Furthermore, no medication, beverage or food with vaso-dilatory or
vaso-constrictive effects should be taken before the study (< 24 hours).
Heidelberglaan 100
3584 CX Utrecht
Nederland
Heidelberglaan 100
3584 CX Utrecht
Nederland
Listed location countries
Age
Inclusion criteria
- 18 years or older
Exclusion criteria
- Impossibility to undergo MRI (claustrophobia, metal objects in or around the body).
- Within 24 hours of MRI scan the use of medication, beverages or food with vaso-
dilatory or vaso-constrictive effects
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18591.041.07 |