The aim of this study is to test the hypothesis that obesity and the microbial community in the human GI tract are linked
ID
Source
Brief title
Condition
- Metabolism disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
From 40 monozygotic twin pairs the bacterial composition of their fecal
microbiota, their weigth, length and BMI will be determined. Within each pair
comparisons between the microbiotas will be made at different taxonomic levels.
These pair-wise comparisons will determine if significant differences exists
between pairs with different bmi compared to those having a similar bmi.
Secondary outcome
Not applicable: 0
Background summary
Several studies have indicated that the host-genotype related factors have an
important role on the microbial community in the GI tract. In addition, energy
efficiency and balance of humans have also clear genetic links. Energy harvest
starts with digestion of dietary components in the GI tract in which microbes
play an important role. This motivated us to form the hypothesis that energy
efficiency and thus obesity might be linked to the microbial community in the
GI tract.
Study objective
The aim of this study is to test the hypothesis that obesity and the microbial
community in the human GI tract are linked
Study design
This observational study focuses on studying the diversity of microbial
communities in the GI tract of various monozygotic twins in detail and
determine the relation between community structure and the obese phenotype
Study burden and risks
Length, weight and BMI will be measured and fecal samples will be collected
from the volunteers. There are no risks concerning these procedures. In
addition, filling in a questionnaire concerning the personal (gender, age, etc)
and health information of the volunteers will be asked
Hesselink van Suchtelenweg 4
6703 CT Wageningen
Nederland
Hesselink van Suchtelenweg 4
6703 CT Wageningen
Nederland
Listed location countries
Age
Inclusion criteria
-Subjects must be able to understand the written study information and must be able to sign an informed consent
-Twin living separately for more than 5 years
-twin pairs who will differ more than 5 kg/m2 in Body Mass Index (BMI)
-Twin pairs who will have a similar BMI
-Where possible a sibling, not older/younger than 5 years than the twin, will be included
Exclusion criteria
Recent history (i.e. last month) or current use of medication that may affect the intestinal microbiota.
-Use of pre- and/or probiotics (for at least one month before collection of the fecal samples).
-Pre-exiting bowel diseases
-Pregnancy/breast feeding
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18323.081.07 |