To investigate the maintaining factor of mood-congruent memory bias of depression, the circumstances when they occur and the neural correlates of these.
ID
Source
Brief title
Condition
- Mood disorders and disturbances NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Study 1:
• Reaction Times (RTs)
• Behavioral memory performance
• Neuropsychological testing
• Questionnaires
• Structural magnetic resonance imaging (sMRI)
Study 2:
• Behavioral memory performance
• Neuropsychological testing
• Questionnaires
• Structural magnetic resonance imaging (sMRI)
• Functional magnetic resonance imaging (fMRI)
Secondary outcome
n.t.v.
Background summary
Memory bias is the most important cognitive maintaining factor of Major
Depressive Disorder (MDD), but the underlying neurobiology and the
participation of particular automatic (implicit) memory processes are still
poorly understood. A better dissociation of the kind of memory supporting
memory bias on the behavioral level and the brain regions mediating memory bias
in depression will enlarge insights about the disease itself thereby allowing
to improve prevention methods of new relapses and neurobiological interventions
during an acute stage of MDD
Study objective
To investigate the maintaining factor of mood-congruent memory bias of
depression, the circumstances when they occur and the neural correlates of
these.
Study design
1. Behavioral study (observational) (Study 1).
2. fMRI study (observational) (Study 2).
Study burden and risks
Study 1: The risks and burdens are minimal to the participant.
Study 2: Risks associated with scanning at an fMRI scanner. Further, the
risks and burdens are minimal to the participants.
P.O. Box 9101
6500 HB Nijmegen
NL
P.O. Box 9101
6500 HB Nijmegen
NL
Listed location countries
Age
Inclusion criteria
MDD Diagnose DSM-IV
Hamilton Rating Scale for Depression score >=17
Exclusion criteria
current or past (hypo)manic episode
current or past alcohol or substance abuse or dependence
left-handed
bad, not correctible vision
history of severe neurological or somatic disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17150.091.07 |