Primary aim1. To determine discriminatory CGT values in *stable* ICU patients who are able to tolerate enteral nutrition meeting their full protein-energy requirementsSecondary aims2. To determine the effects of enteral and intravenous glutamine…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
stabiele intensive care patienten met allerlei onderliggende aandoeningen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The determination of discriminatory CGT values in *stable* ICU patients who
are able to tolerate enteral nutrition meeting their full protein-energy
requirements
enteral enery losses (using bomb calorimetry)
Secondary outcome
The determination of the effects of enteral and intravenous glutamine
administration on CGT values in these patients.
The assessment of differences in plasma citrulline concentrations following
venous and arterial blood sampling, respectively
Background summary
At present there is no feasible test available for the assement of enterocyte
function as a measure of the absorptive capacity of the small bowel. In
patients with known enterocyte dysfunction (IBD, coeliac disease) stimulation
of the enterocytes by a glutamine load (The Citrulline Generation Test) a
socalled subnormal resposne has been demonstrated by our group. One could
specualte on the frequent occurrence of intstinal failure in critically ill
patienst mainly due to ischemia of the digestive tract.
In this study proposal we aim to assess discriminatory values for the
*citrulline generation test* (CGT) in 12 *stable* ICU patients on full enteral
nutrition without any known small intestinal disorders. Additional aims are to
determine differences in CGT curves obtained following enteral and intravenous
administration of alanine-glutamine and to assess differences in plasma
citrulline concentrations following venous and arterial blood sampling,
respectively.
Study objective
Primary aim
1. To determine discriminatory CGT values in *stable* ICU patients who are able
to tolerate enteral nutrition meeting their full protein-energy requirements
Secondary aims
2. To determine the effects of enteral and intravenous glutamine administration
on CGT values in these patients.
3. To assess differences in plasma citrulline concentrations following venous
and arterial blood sampling, respectively.
Study design
prospective cohort study
Intervention
The citrulline generation test.
Study burden and risks
Dipeptiven administration is part of our routine nutritional therapy, mainly as
an adjunctive to TPN. No clear side effcts are known.
Sampling is performed from existing blood lines, without the need for extra
punctures. The total amount of blood collection is 72 ml.
For the 2 CGTs the patient needs to fast for at least 6 hrs. The enteral
nutrition will therefor be withdrawn, while we wil closely watch glucose levels.
Feces collection is routine on the ICU using special collection bags. No
disconfort will be noted by the patient.
Postbus 7057
1007 MB Amsterdam
Nederland
Postbus 7057
1007 MB Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
1. age between 18-80
2. informed consent
3. fecal production< 250 gr/24 hrs
4. stable ICU patient
5. full enteral nutrition
Exclusion criteria
no signs of malabsorption, liver cirrhosis, steroids (> 10 mg/dag), pregnancy, partenteral nutrition
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18743.000.07 |