Visualization of the MGU and it*s borders on MRI scans of women without cervical cancer.
ID
Source
Brief title
Condition
- Reproductive neoplasms male malignant and unspecified
- Cervix disorders (excl infections and inflammations)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
On subsequent transverse T2 weighted images identification of the
(subperitoneale uterovaginal) morphogenetic unit: cervical fibrous stroma (low
signal intensity) and the dorsally horseshoe-shaped ligamentous mesometrium,
utero sacral ligament (intermediate - low signal intensity).
On subsequent T2 weighted transverse and coronal images distinction of the
morphogenetic unit from the bladder, bladder mesenteries (vesico uterine
ligament), ureters, main pelvic autonomic-nerve plexus and the mesorectum
(bordered by low signal intensity mesorectal fascia).
Secondary outcome
inter observer variability
intra observer variability
Background summary
According to an existing new theory, growth of a primary cervical carcinoma is
restricted to an embryological predisposed area called the morphogenetic unit
(MGU) for a long phase during malignant progression. Macroscopic, microscopic,
and occult local tumour spread should be confined to the aforementioned area.
The MGU and its borders have been identified in female embryos of different
gestational ages. During the surgical procedure the surgeon has to identify the
borders of the MGU, and operate according to them. In surgical practice, this
has been looked upon as feasible. Furthermore, a bordering lamella between the
different parts of the ligamentum vesico-uterina, which has parts that do and
parts that do not belong to the MGU, has been described in the literature.
Study objective
Visualization of the MGU and it*s borders on MRI scans of women without
cervical cancer.
Study design
Observational study.
A single MRI will be performed by a 3 Tesla MRI scanner. Images will be studied
by two different radiologists to find a clearly recognizable bordering
structure, using criteria that were defined on beforehand.
Study burden and risks
The MRI scan itself has no known adverse effects when performed on people
withouth contra indications.
Buscopan (i.m.) is frequently and according to protocols used for abdominal MRI
scans. Side effects are seldom and/or moederately severe.
Albinusdreef 2
2333 ZA Leiden
Nederland
Albinusdreef 2
2333 ZA Leiden
Nederland
Listed location countries
Age
Inclusion criteria
healthy (no pelvic pathology)
pre menopausal
Exclusion criteria
medical history of pelvic surgery or pelvic patholgy
(post) menopause
contra indications for MRI
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17823.058.07 |