To examine whether platelet hyperreactivity, as assessed by various platelet activation or function tests, could explain recurrence of cardiovascular events among patients that suffered a first MI.To assess which (combination of) platelet activation…
ID
Source
Brief title
Condition
- Myocardial disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The composite of cardiovascular death; nonfatal MI; nonfatal ischemic stroke;
unstable angina; coronary, carotid or peripheral revascularisation; and
peripheral artery disease needing amputation as a result of ischemia.
Secondary outcome
NA
Background summary
Recurrent cardiovascular events may be predicted by (a combination of) platelet
activation or function tests among patients that suffered a first myocardial
infarction (MI).
Study objective
To examine whether platelet hyperreactivity, as assessed by various platelet
activation or function tests, could explain recurrence of cardiovascular events
among patients that suffered a first MI.
To assess which (combination of) platelet activation or function tests most
reliably predict recurrent cardiovascular events among patients that suffered a
first MI.
Study design
Prospective cohort study (and a nested case-control study within this same
cohort) among patients who survived a first MI.
Cases: patients with recurrent cardiovascular disease after first MI
Controls: patients without recurrent cardiovascular disease after first MI
Study burden and risks
The burden associated with participation is very low: participants have to come
once to our research centre. They will be asked to complete one questionnaire
and a venapuncture will be performed. There are no risks associated with
participation.
Postbus 9600
2300 RC Leiden
Nederland
Postbus 9600
2300 RC Leiden
Nederland
Listed location countries
Age
Inclusion criteria
Cases: recurrent cardiovascular event after inclusion in the SMILE-study
Control subjects: event-free after inclusion in the SMILE-study
Exclusion criteria
Severe neuropsychiatric disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18657.058.07 |