Testing the hypothesis that stromal reflectivity, assessed by confocal microscopy, is a reliable quantitative measure for the inflammatory process due to HSV keratitis.
ID
Source
Brief title
Condition
- Ocular infections, irritations and inflammations
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Confocal microscope:
Stromal reflectivity (Z-scan, Area Under the Curve (AUC)) of HSV eye.
- Clinical scoring form.
Secondary outcome
- Confocal microscope:
Stromal reflectivity (Z-scan, AUC) fellow eye,
Stromal reflectivity after 10 minutes HSV Eye (test reproducibility),
Total corneal reflectivity,
Reflectivity of anterior, median and posterior stroma separately.
- Pachymetry:
Tomey,
Pentacam.
- Slit lamp (maximal resolution):
photograph central cornea,
photograph paracentral cornea,
blue light photograph (fluorescein drop),
overall corneal photography.
- Clinical scoring form based on slit lamp photography.
- Vision:
BCVA (ETDRS chart),
Contrast sensitivity (Pelli-Robson chart),
Intraocular stray light (Oculus C-quant).
Background summary
Confocal microscopy is a non-invasive, real-time, in vivo imaging technique
which has been put forward as a potential clinical tool for inspection of the
cornea. Presently, active Herpes Simplex Virus-1 (HSV) keratitis is evaluated
by slit lamp inspection. For an objective follow up of the inflammatory
process, however, this method does not meet the standards of sufficient
accuracy and reproducibiltiy. In this study, it will be investigated whether
the improved image quality of the most recent version of the confocal
microscope can provide a reliable quantitative parameter for a more adequate
follow up of the inflammatory process of active HSV keratitis.
Study objective
Testing the hypothesis that stromal reflectivity, assessed by confocal
microscopy, is a reliable quantitative measure for the inflammatory process due
to HSV keratitis.
Study design
Prospective cohort study.
Study burden and risks
Study-related measurements will be performed during clinical visits and will
take approximately 40 minutes extra time. Participants of this study do not
benefit from the results of this study. Risks are negligible.
Schiedamse Vest 180
3011 BH Rotterdam
Nederland
Schiedamse Vest 180
3011 BH Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Age >=18 years.
Informed consent.
Unilateral active keratitis.
Exclusion criteria
Corneal irregularity.
Recently deteriorating cataract.
Recently deteriorating retinal lesion.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17615.078.07 |