Correlation of FDG uptake and in vitro aneurysm wall tensile strength. (primary objective). The effect of aneurysm sac depressurisation, after endovascular aneurysm repair, on aneurysm wall inflammation (secondary objective).
ID
Source
Brief title
Condition
- Vascular therapeutic procedures
- Aneurysms and artery dissections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Standard uptake value (SUV) measurements to asses FDG uptake in the aneurysm
wall and in vitro aneurysm wall strength (N/mm).
Secondary outcome
Plasma and urine levels of inflammatory biomarkers (e.g. CRP).
Background summary
Aneurysm development, progression and rupture are characterised by extensive
inflammation, dominated by the infiltration of T-cells, B-cells and
macrophages. Recent studies into the pathophysiology of aneurysm wall
degradation suggest a close relation between increased mechanical stress and
the local activation of infiltrated lymphocytes and macrophages. The
non-invasive detection of aneurysm wall inflammation, using
18-fluorodeoxyglucose positron emission tomography (FDG-PET) might therefore
provide valuable information on the extend of the disease and could clarify the
role of mechanical stress on the propagation of aneurysm wall inflammation.
Study objective
Correlation of FDG uptake and in vitro aneurysm wall tensile strength. (primary
objective). The effect of aneurysm sac depressurisation, after endovascular
aneurysm repair, on aneurysm wall inflammation (secondary objective).
Study design
Observational case series (pilot).
Study burden and risks
Patients scheduled for conventional (open) or endovascular aneurysm repair are
admitted to the hospital the day before surgery. At that point all patients
will be evaluated using FDG-PET/CT. Although intake of sugar-free liquids is
permitted, glucose intake is restricted 6 hours prior to FDG-PET imaging. One
hour after intravenous injection of 200-220 MBq FDG, whole body emission and
transmission images will be acquired. To determine inflammation markers ( e.g.
CRP), blood and urine samples will be collected prior to the operation and
again 6 weeks after surgery. For in vitro aneurysm wall tensile strength
testing wall specimens will be harvested during conventional aneurysm repair.
To study the influence of bloodpressure on aneurysm wall inflammation, a second
FDG-PET/CT will be performed 6 weeks after the endovascular treatment of the
aneurysm.
Geert Grooteplein 10
6500 HB Nijmegen
Nederland
Geert Grooteplein 10
6500 HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
1. Patients scheduled for conventional (open) or endovascular aneurysm repair.
2. Informed consent.
Exclusion criteria
1. Diabetes Mellitus Type 1 and 2
2. Ruptured abdominal aortic aneurysm.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17447.091.07 |