Measuring difference in the conditioning between migraineurs and healthy volunteers, by using the eyeblinker.
ID
Source
Brief title
Condition
- Headaches
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The eye-blink difference between migrainepatients and controls.
Parameters: CR/UR amplitude, CR/UR onset, CR/UR Peakamplitude and the CR/UR
Peaktime gebruikt (CS= conditioned respons US= unconditioned respons)
Secondary outcome
The sensitivity of trigeminus system by migrainepatients compared with controls.
Do the results of the disturbed conditioned corresponds to a
coordinationdisorder measured by the sway-test?
The relations between the contols, the migrainepatients and the patients with a
degenerative disease.
Background summary
Earlier examinations possibly shows small damages of the cerebellum in patients
with migraine, especially in patients with aura. These defects are structural
as well as functional. It is also shown that conditioning largely takes place
in the cerebellum. The eye-blinker is a valid method to measure conditioning.
The Sway-test is a good methode to measure the coordination and to detect
minimal movements.
Study objective
Measuring difference in the conditioning between migraineurs and healthy
volunteers, by using the eyeblinker.
Study design
a cross section examination
Controls versus migrainepatiënts with aura
Study burden and risks
The volunteers are asked to come to the LUMC. First the volunteers will be
asked to give answers on simple questions about their health, use of medicines
and their vision. This will take 5 minutes. The test will consist of 8 trials
of 6 minutes. A conditioned respons will be generated by using airpuffs and
tones. After 8 trials the coordination will be tested by a sway-test. The total
duration of the tests will be less then 90 minutes.
Albinusdreef 2
233 AZ Leiden
Nederland
Albinusdreef 2
233 AZ Leiden
Nederland
Listed location countries
Age
Inclusion criteria
Patients with migraine and aura with minimal 6 attacks a year (2 with aura).
Healthy volunteers without migraine.
Patients with a cerebellar degenerative diseases
Exclusion criteria
For the migrainepatients and healthy controls: Neurologic diseases in which the function of cerebellum is disturbed.
The use of medicines/drugs which have influence on the coordination 24 hours before taking part of this examination.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL16940.058.07 |