The aim of this study is to identify cow's milk protein T cell specific epitopes in children with cow's milk allergy. The results of this study will be implemented in a controlled, prospective follow-up study, *Cow*s milk allergy: a clue…
ID
Source
Brief title
Condition
- Allergic conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To identify cow's milk protein T cell specific epitopes in children with CMA.
Secondary outcome
To investigate the T Cell specific cytokine production induced by these
epitopes in children wit CMA.
Background summary
The incidende of allergic disorders has increased during the last decades.
Cow's milk allergy (CMA) is the most common allergic disorder in early infancy
and is the precursor of other allergic disorders as asthma, atopic dermatitis
and hay fever ("the allergic march"). CMA is a multi-organ disaese and most
children become tolerant for cow's milk protein (CMP), but the subsequent
development of additional allergic disorders is substantial. The mechanisms
behind these phenomena are poorly understood.
Study objective
The aim of this study is to identify cow's milk protein T cell specific
epitopes in children with cow's milk allergy. The results of this study will be
implemented in a controlled, prospective follow-up study, *Cow*s milk allergy:
a clue in understanding the allergic march?* (MEC 05/254).
.
Study design
Case study
Study burden and risks
During a routine blood draw an extra amount of blood (10ml) will be collected.
Emla cream will be used to numb the skin of the child before the blood draw.
There are no risks associated with participation in this study other then the
risks associated with a routine venous blood draw. There are no benefits for
the children participating in this study.
Meibergdreef 9
1105 AZ amsterdam
Nederland
Meibergdreef 9
1105 AZ amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Children with CMA, 1-12 years of age.
Exclusion criteria
None
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15710.018.08 |