To analyze the change in lymphatic mapping in HNSCC patients treated by primary radiation therapy on the primary tumor and neck.
ID
Source
Brief title
Condition
- Respiratory and mediastinal neoplasms malignant and unspecified
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Alteration of lymphatic drainage after primary radiation therapy.
Secondary outcome
none
Background summary
Treatment of lymph nodes is based on the knowledge that the pattern of
metastatic spread is predictable, and related to site, size and
histopathological status of the primary tumor. However, any disturbance of
normal drainage by radiotherapy can result in other pathways of lymphatic
drainage with dissemination of cancer cells. Lymphoscintigraphy is able to
supply a complete map of the lymphatic drainage and thereby tailoring treatment
which may minimise the extent of under- and overtreatment.
Study objective
To analyze the change in lymphatic mapping in HNSCC patients treated by primary
radiation therapy on the primary tumor and neck.
Study design
This is an observational non-randomized single-institute pilot study.
Study burden and risks
Lymphoscintigraphy is a procedure which is used routinely in other tumor types.
In the literature on head and neck cancer no serious adverse events have been
reported using these techniques.
De Boelelaan 1117
1081 HV
Nederland
De Boelelaan 1117
1081 HV
Nederland
Listed location countries
Age
Inclusion criteria
Patients with squamous cell carcinoma of the head and neck
Scheduled for primary irradiation of the primary tumor and neck
Primary tumor accessible for peritumoral injection of radiolabeled colloid
No clinical lymph node metastases pretreatment
No previous neck pathology or treatment to the primary tumor or neck (surgery, radiotherapy or chemotherapy) that may alter lymphatic drainage
Exclusion criteria
age < 18 or > 80 years
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL21087.029.07 |