to study the effect of short term combined use of NSAIDS with diuretics/RAAS-inhibitors on the heart and kidneyfunction in orthopedic patients undergowing a knee- or hip-replacement
ID
Source
Brief title
Condition
- Heart failures
- Joint disorders
- Renal disorders (excl nephropathies)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- systolic bloodpressure
- diastolic bloodpressure
- glomulair filtration rate
Secondary outcome
- oedema
- serum creatinine
- serum Na+
- serum K+
- consult cardiology/internal
- dose reduction/escalation diuretics/RAAS-inhibitor
Background summary
a clinical relevant interaction is know between diuretics/RAAS-inhibitors use
of NSAIDS. Only of the long-term use of this combination has the clinical
relevance been esthablished.
In patients undergowing knee- or hip-replacement surgery NSAIDS are used to
prevent heterotopic ossification, also in this combination
Study objective
to study the effect of short term combined use of NSAIDS with
diuretics/RAAS-inhibitors on the heart and kidneyfunction in orthopedic
patients undergowing a knee- or hip-replacement
Study design
prospective, controlled, clinical observational study
Study burden and risks
during clinical admission;
- extra bloodpressure measurements
- extra oedema measurements
- extra bloodsample (one)
takeing a bloodsample kan be painful and can possibly cause bruiseing
Ceintuurbaan 4a
7415HL
Nederland
Ceintuurbaan 4a
7415HL
Nederland
Listed location countries
Age
Inclusion criteria
elective knee- or hipreplacement
use of RAAS-inhibitors and diuretics
Exclusion criteria
hipfracture with replacement
revision of the knee or hip
hospitalisation <4 days
nephrotoxic drugs
other medication use with possible NSAID's interactions
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17822.075.07 |