The hypothesis is that women who have the Ser680Ser (SS) variant of the FSH receptor genotype, in comparison with women with the Ser680Asn (NS) or Asn680Asn (NN) variant, are less sensitive to FSH and because of that need higher dosages of FSH when…
ID
Source
Brief title
Condition
- Endocrine disorders of gonadal function
- Sexual function and fertility disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
-The FSH receptor polymorphism genotype.
-The number of growing follicles and retrieved oocytes per treatment cycle.
Secondary outcome
Not applicable.
Background summary
A poor response to FSH stimulation in IVF or ICSI, implicates either limited
ovarian reserve or relative insensitivity of the ovary to FSH. In particular
with a less sensitive ovary some benefit may be expected from a dose increase
of FSH in a next cycle. We aim to research whether it is useful to stimulate
poor responders with a higher dosage of FSH in a short protocol when they have
a presumed less sensitive FSH receptor polymorphism genotype.
Study objective
The hypothesis is that women who have the Ser680Ser (SS) variant of the FSH
receptor genotype, in comparison with women with the Ser680Asn (NS) or
Asn680Asn (NN) variant, are less sensitive to FSH and because of that need
higher dosages of FSH when they are treated for subfertility.
This could confirm a predictor function of the FSH receptor polymorphism
genotyping in the treatment of poor responders.
Study design
Retrospective chart review. Pilot study for a future prospective study.
Study burden and risks
-One blood sample, taken in the clinic or at home
-No risk and no direct benefit for the patient however future subfertility
patients may benefit from the outcome of this study.
De Boelelaan 1117
1007 MB Amsterdam
Nederland
De Boelelaan 1117
1007 MB Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Inclusion criteria are 2 ovaries in situ, less than 1,5 years between the two treatments, the use of a GnRH-agonist in the short protocol using 450 units of FSH, a minimum of one previous IVF or ICSI cycle in which the dosage FSH was less than 450 units of FSH (i.e. 225 or 300 IU/day), a long suppression protocol and a GnRH-agonist was used.
Exclusion criteria
Exclusion criteria are removal of one ovary, more than 1,5 years between the treatments, the use of a GnRH-antagonist and no previous IVF/ ICSI cycle(s) or previous cycles in which the dosage was also 450 units of FSH or a short protocol was used.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18880.029.07 |