The aim of this study is to classify hyothalamic dysfunction in patients treated for pituitary tumors. The hypothalamic functions will be investigated in different studygroups, these groups each have a different risk on hypothalamic dysfunction.
ID
Source
Brief title
Condition
- Hypothalamus and pituitary gland disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Sleep analysis by polysomnography
2. 24 hour bloodpressure and heartbeat.
3. 24 hour temperature regulation
4. 24 hour rhythm of leptine and melatonine
5. fasting lipids and post-prandial lipids.
6. quality of life questionnaires
7. sleep diary and sleepquestionnaires
8. sleepregistration by actigraphy
9. ambulant polysomnography
10.virgilancy test
Secondary outcome
not applicable
Background summary
Patients treated for pituitary tumors have a higher morbidity and mortality.
The explanation for the higher morbidity is often searched for in
hypopituitarism, however the morbidity exists despite adequate hormone
replacement. An explanation could be that the pituitary tumors or the effects
of treatment of these tumors (surgery/radiation) leads to hypothalamic damage
with as a consequence hypothalamic dysfunction.
Study objective
The aim of this study is to classify hyothalamic dysfunction in patients
treated for pituitary tumors. The hypothalamic functions will be investigated
in different studygroups, these groups each have a different risk on
hypothalamic dysfunction.
Study design
This study has a cross-sectional design and studies the patients discribed in
the next text box.
Study burden and risks
non of the measurements have any risks.
albinusdreef 2
2333 ZA Leiden
Nederland
albinusdreef 2
2333 ZA Leiden
Nederland
Listed location countries
Age
Inclusion criteria
informed consent
tendency to judge
in patients treated for a non-functioning pituitary adenoma:
-representative ITT
-six months of adequate substitution of pituitary hormones
Exclusion criteria
pregnancy
diagnosed sleepdisorder
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL20195.058.07 |