1. To compare patient outcomes during follow-up between adherents versus non-adherents with psychoeducation in patients with schizophrenia. We selected *time to (re)hospitalisation* as the most important outcome.2. To assess the prevalence and risk…
ID
Source
Brief title
Condition
- Schizophrenia and other psychotic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Time to (re)hospitalisation.
Secondary outcome
- The prevalence and risk factors of non-adherence with psychoeducation in
patients with schizophrenia.
- adherence with antipsychotics, change in medication regimen, global
functioning, quality of life, living situation and occupation between adherents
and non-adherents with psychoeducation.
Background summary
Schizophrenia is characterised by psychotic relapses and hospitalisations.
Antipsychotics are the main medical treatment to reduce symptoms and prevent
psychotic relapses. However, non-adherence with antipsychotics is common in
patients with schizophrenia. Psychoeducation is an additional effective
intervention in reducing relapses and rehospitalisation rates.
However, we conducted a systematic review on non-adherence with psychoeducation
in patients with schizophrenia to assess the prevalence, the risk factors of
non-adherence and patient outcomes of adherents versus non-adherents. We
concluded that there is a lack of data in the published literature.
In this cohort study we will study the difference in patient outcomes between
adherents versus non-adherents with psychoeducation and we will assess the
prevalence and risk factors of non-adherence. If, for example, substantial
proportions of patients do not adhere and non-adherence with psychoeducation -
like non-adherence with antipsychotics - would increase the risk of relapse,
the development and testing of interventions to improve adherence would become
more urgent. Secondly, the specific risk factors found may help to develop
interventions so health care professionals can target their interventions to
minimise non-adherence with psychoeducation.
Study objective
1. To compare patient outcomes during follow-up between adherents versus
non-adherents with psychoeducation in patients with schizophrenia. We selected
*time to (re)hospitalisation* as the most important outcome.
2. To assess the prevalence and risk factors of non-adherence.
Study design
Multi-centre prospective cohort study with candidate predictors assessed at
baseline and outcome variables at 6 months intervals during follow-up
Study burden and risks
We expect that participation will have no positive or negative consequences for
the patients themselves. That is, participation will not jeopardise the
emotional or physical health of the participants; the impact will not paralyse
daily functioning or cause (severe) trauma to participants. However, the
assessments in patients will take 2 and 1/2 hour of the patients* time, in 3 or
5 contactmoments.
Heidelberglaan 100
3584 CX Utrecht
NL
Heidelberglaan 100
3584 CX Utrecht
NL
Listed location countries
Age
Inclusion criteria
- Dutch speaking patients with schizophrenia spectrum disorders according to DSM-IV criteria
- Age: 18 years and above
- Offered to start group psychoeducation
Exclusion criteria
- Less than two years of high school/secondary school
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22000.041.08 |