The aim of this research is to determine the effect of glucose in the small intestine on the secretion of hormones, appetite related feelings and food intake, and whether these effects differ between time of day (morning vs evening) and segment of…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
overgewicht
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Endpoints of the research are differences in satiety, food intake, and changes
in hormone concentrations between the conditions.
Secondary outcome
Differences between conditions in thirst or nausea.
Background summary
Overweight is a big and still growing health-related problem.
For many years reserach has been conducted to gain insight into the effects of
specific nutrients that may influence hunger related feelings and food intake.
The small intestine has proven to be of great importance for the satiating
effects of nutrients. Recent findings showed that infusion of fat in the small
intestine lowers feelings of hunger and lowers energy intake. Little is known
about the effects of carbohydrates (glucose) on the small intestine. It is
known that the human body reacts differently to an oral glucose load in the
morning compared to an oral glucose load in the evening. Possibly these
differences can be partially explained by different effects of glucose on the
small intestine.
Study objective
The aim of this research is to determine the effect of glucose in the small
intestine on the secretion of hormones, appetite related feelings and food
intake, and whether these effects differ between time of day (morning vs
evening) and segment of the small intestine (duodenum vs ileum).
Study design
Both studies will have a randomised dubbelblind crossover design with 3
conditions. The randomisation of the conditions will be done digitally.
Intervention
The subjects receive in the duodenal as well as in the ileal study:
- an oral glucose drink in the morning and in the evening
- an infusion with glucose in the duodenum or ileum, in the morning and in the
evening
- an infusion with saline in the duodenum or ileum, in the morning and in the
evening
Study burden and risks
This research includes little risks for the subjects. The insertion of the
catheter via the nose is a routinely used technique at the Academical Hospital
Maastricht, and is at this moment the only technique to infuse glucose in a
specific part of the small intestine. The information obtained from this
protocol is, however, of great importance for research on the effects of
nutrients in the small intestine.
postbus 616
6200MD Maastricht
Nederland
postbus 616
6200MD Maastricht
Nederland
Listed location countries
Age
Inclusion criteria
Healthy male or female, aged 18-55 years and a Body Mass Index (BMI) of 18-29 kg/m2
Exclusion criteria
Evidence of severe diseases, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol. Gastrointestinal or hepatic disorders influencing gastrointestinal absorption or transit. Use of psychotropic drugs. Alcohol in excess of 21 units/week for males and 14 units/week for females. Concomitant medication that can increase gastric pH, or alter gastric emptying, or alter intestinal transit, or influence satiety/energy intake. Pregnancy, lactation, wish to become pregnant during study, or having a positive pregnancy test at inclusion. Reported unexplained weight loss/gain of more than 2 kg in the month before the study enrollment. Score > 9 on Factor 1 (dietary restrained) of the Dutch translation of the Three Factor eating Questionnaire (TFEQ). Blood donations less than three months previous to study enrollment. One or more of the following dietary habits: medically prescribed diets, weight reduction diets, or vegetarian/macrobiotic/biologically dynamic food habits. Reported working on late/night shifts.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22782.068.08 |