The purpose of this study is to investigate the association between T cell compartment composition and vitamin D status in MS patients, with particular interest for regulatory T cell functionality.
ID
Source
Brief title
Condition
- Autoimmune disorders
- Central nervous system infections and inflammations
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Composition of the T cell compartment and vitamin D status
Secondary outcome
Functionality of regulatory T cell population
Background summary
Vitamin D is a potent immune modulator in vitro, which brings the T cell
compartment in a less pro-inflammatory state. Hereby, low levels of the most
prominent metabolite of vitamin D, 25-hydroxyvitamin D (25(OH)D), are
associated with a high multiple sclerosis incidence and severity. From
experimental animal studies, there are indications that a modulation of the T
cell compartment is responsible for this association. (Smolders et al. Vitamin
D as an immune modulator in multiple sclerosis, a review. J Neuroimmunol.
2008;194(1-2):7-17).
Study objective
The purpose of this study is to investigate the association between T cell
compartment composition and vitamin D status in MS patients, with particular
interest for regulatory T cell functionality.
Study design
Cross-sectional association study
Study burden and risks
The invasive intervention is the aquisition of 60cc blood by a venous puncture.
The risk on side-effects (heamatoma or vagal reaction) is small and these side
effects are passing things. For severely disabled patients, an additional
journey to the hopsital can be aggrevating. Therefore, by request we visit the
patient at home for the venous puncture.
PO Box 616
6200 MD Maastricht
Nederland
PO Box 616
6200 MD Maastricht
Nederland
Listed location countries
Age
Inclusion criteria
Clinical definite MS (McDonald criteria)
Relapsing Remitting clinical phenotype
Exclusion criteria
The use of other immune-modulating medicine than Interferon Beta
Recent start (<=0,5 year) of vitamin D supplementation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22666.096.08 |