To investigate the difference between two meals (high in protein vs. high in carbohydrates) on the endothelial function?
ID
Source
Brief title
Condition
- Vascular hypertensive disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Endothelial function, measured by forearm blood flow before and after arterial
occlusion
Secondary outcome
not applicable
Background summary
A healthy endothelium regulates the balance between vasodilation and
vasoconstriction. On the other hand dysfunction of the endothelium is a
precursor for cardiovascular diseases such as atherosclerosis. Lifestyle
interventions can improve endothelial functioning. Interventions can be
exercise as well as dietary interventions. At this point little is known about
the short term effect of a meal high in protein or carbohydrates.
Study objective
To investigate the difference between two meals (high in protein vs. high in
carbohydrates) on the endothelial function?
Study design
In random subjects will ingest a protein or carbohydrate-rich meal on two
different days. Before and during 2 hours after the meal forearm blood flow
will me measured before and after 5 minutes of arterial occlusion.
Intervention
Intervention meal .1=30% protein, 30% fat, 40% carbohydrates. 2=12% protein,
30% fat, 58% carbohydrates.
Study burden and risks
Time burden is 2*2.5 hours. No further risks
Universiteitssingel 50
6200 MD Maastricht
Nederland
Universiteitssingel 50
6200 MD Maastricht
Nederland
Listed location countries
Age
Inclusion criteria
Healthy, between 20-40 years
Exclusion criteria
Smoking, currently on medication, high blood pressure (>160 mmHg systolic, >100 mmHg diastolic), BMI >35 kg/m2
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22424.068.08 |