The main objective of the study is: what are normal values for TMS parameters of arm extensor muscles in healthy human subjects? Secondary objectives are: (1) which forearm extensor muscle is most appropriate for a TMS study and (2) what is the…
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are the determinants of the S-R curves of MEP AUC and
SP, which are slope, plateau value and X-intercept of the tangent.
Secondary outcome
The secondary study parameters comprise the outcomes of a questionnaire (visual
analog scale - VAS) concerning experienced pain and discomfort of the TMS
procedures.
Background summary
Rationale: This study is an extension of the study of A.A. van Kuijk on the
predictive value after a cerebro-vascular accident (CVA) of motor evoked
potentials (MEPs) and silent periods (SPs) as evoked in arm muscles with
transcranial magnetic stimulation (TMS).The value of extension of the upper
extremity as a predictive measure for long-term functional recovery after a CVA
has been established, but corresponding TMS parameters of arm extensor muscles
remain to be explored. Since studying these muscles with TMS represents a novel
approach, first reference values in healthy controls and interobserver validity
of the measurements need to be substantiated.
Study objective
The main objective of the study is: what are normal values for TMS parameters
of arm extensor muscles in healthy human subjects? Secondary objectives are:
(1) which forearm extensor muscle is most appropriate for a TMS study and (2)
what is the interobserver variability of a TMS study of the arm extensors?
Study design
Cross-sectional study
Study burden and risks
Theoretically, people undergoing TMS could develop an epileptic insult.
However, few incidents have been described. No other risks are known. It is
expected that TMS of arm extensors can significantly contribute to knowledge
and therapy aims in CVA patients, and the risks are considered minimal in
comparison to the benefits of the study.
Postbus 9101
6500 HB Nijmegen
Nederland
Postbus 9101
6500 HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
age over 18 years
capable of understanding written and verbal information
capable of following verbal instructions
Exclusion criteria
history of neurological damage or disease
recent history of injury or disease involving an upper extremity
history of psychiatric disease
history of seizures or epilepsy
pacemaker or other metal implants in the upper body
pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22925.091.08 |