To establish platelet function during orthotopic liver transplantation.
ID
Source
Brief title
Condition
- Hepatic and hepatobiliary disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Development of functional properties of vWF during and after OLT.
Development of functional properties of platelets during and after OLT.
Circulation of partly activated platelets during OLT (especially after
reperfusion).
Secondary outcome
Transfusion requirements, which contains all crystalloids, colloids and blood
products as RBCs, FFPs and Trombocytes, during the operation.
Hepatic artery thrombosis.
total blood loss.
Background summary
Despite considerable progress in surgical techniques, orthopic liver
transplantation (OLT) is still associated with significant blood loss,
resulting in requirement for transfusion of blood products in an substantial
number of patients. Before surgery, patients have poorly characterized,
multifactorial coagulopathic state, which aggravates perioperatively. One of
the contributors to preoperative coagulopathy in patients eligible for OLT is a
qualitative and quantitative blood platelet defect. Little is known, however,
on the perioperative development of platelet function abnormalities.
Study objective
To establish platelet function during orthotopic liver transplantation.
Study design
observational clinical mono-center study.
Study burden and risks
Serial samples, containing blood samples and liver biopsies, will be studies
during and after liver transplantation.
Blood samples: 4 times during surgery and 3 times (day 1,5 and 10) after
surgery.
Liverbiopsies: following standard protocols. two times during surgery and one
week after surgery.
The duration of the study per patient will not be longer than the admission
time of the patient in the hospital. Patients who participate in the study do
not have to come over for extra visits to the hospital.
Hanzeplein 1
9713 GX Groningen
Nederland
Hanzeplein 1
9713 GX Groningen
Nederland
Listed location countries
Age
Inclusion criteria
age > 17 years
first liver transplantation for liver cirrhosis
retransplantation for liver cirrhosis, more than six months after previous OLT.
Exclusion criteria
age < 18 years
retransplantation within six months after first/last transplantation.
presence of metabolic disease
malignancies
Budd-chiari syndrome
portal vein thrombosis
use of aspirin 10 days before surgery.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL21105.042.07 |