1a. To compare metabolic response during ADL between patients with moderate to severe COPD and healthy age-matched control subjects.1b. To compare symptom Borg scores for dyspnoea and fatigue and heart rate during ADL between patients with moderate…
ID
Source
Brief title
Condition
- Heart failures
- Respiratory disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Differences in absolute and relative oxygen uptake and minute ventilation
during ADLs between patients and healthy control subjects.
Secondary outcome
Differences in absolute and relative heart rate and symptom perception for
dyspnea and fatigue during ADLs between patients and healthy control subjects.
Background summary
At present, it remains unknown whether and to what extent patients with
moderate to severe COPD may have a higher oxygen uptake during activities of
daily life (ADL) than healthy control subjects. Nevertheless, based on previous
results, it is reasonable to hypothesize that patients with moderate to severe
COPD have a higher oxygen uptake while performing the same ADL as healthy
age-matched control subjects.
To the best of the knowledge of the steering committee, the metabolic response
during ADL has never been studied in patients with chronic heart failure (CHF).
Nevertheless, CHF patients do self-report serious difficulties with performing
ADL. This however has never been linked to the systemic consequences of the
disease and has never been objectified.
Study objective
1a. To compare metabolic response during ADL between patients with moderate to
severe COPD and healthy age-matched control subjects.
1b. To compare symptom Borg scores for dyspnoea and fatigue and heart rate
during ADL between patients with moderate to severe COPD and healthy
age-matched control subjects.
2a. To compare metabolic response during ADL between patients with moderate to
severe COPD and healthy age-matched control subjects.
2b. To compare symptom Borg scores for dyspnoea and fatigue and heart rate
during ADL between patients with moderate to severe COPD and healthy
age-matched control subjects.
Study design
All designs are cross-sectional comparative.
Study burden and risks
The current research group believes that the nature and possible extent of the
burden and risks possibly related to the present protocol are nihil and
acceptable.
The mobile oxycon has bene used in previous studies in health and in patients
with moderate to very severe COPD during exercise tests [bijvoorbeeld: Probst
et al Chest 2004] and during rehabilitation sessions [Probst et al ERJ 2006]
without any adverse events.
The cardiopulmonary exercise test may be perceived as burdensome by the
patients and the healthy subjects. Nevetheless, this test is necesaary to
provide a refenrence value for the values obtained during ADLs. Moreover, the
test will be done in a specilized surrounding and will be guided by the
laboratory worker and a physician. Finally, the cardiopulmonary exercise test
is part of the clinical assessment of patients before the start of a
rehabilitation program [Spruit et al Lancet 2008].
Kenneth.Meijer@BW.unimaas.nl
6229 ER, Maastricht
Nederland
Kenneth.Meijer@BW.unimaas.nl
6229 ER, Maastricht
Nederland
Listed location countries
Age
Inclusion criteria
Chronic obstructive pulmonary disease (GOLD I to IV)
Chronic heart failure (NYHA I to IV)
Exclusion criteria
Neurological diseases, endocrine diseases, locomotor diseases, long-term oxygen therapy (LTOT)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL22292.068.08 |