First, to develop a diagnostic method for non-infectious uveitis in childhood. Second, to analyze iris and ciliary body tissues of children with uveitis on the presents of inflammatory infiltrate. The results of this study will contribute in the…
ID
Source
Brief title
Condition
- Anterior eye structural change, deposit and degeneration
- Autoimmune disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
First, protein profiles in the aqueous humor of children with uveitis. Second,
inflammatory infiltrates in tissue fragments of iris and ciliary body of
children with uveitis.
Secondary outcome
na
Background summary
Specific knowledge about cause and treatment of uveitis in childhood is for the
present inadequately available in literature since uveitis in childhood is
rare.
Study objective
First, to develop a diagnostic method for non-infectious uveitis in childhood.
Second, to analyze iris and ciliary body tissues of children with uveitis on
the presents of inflammatory infiltrate. The results of this study will
contribute in the diagnostics of uveitis in childhood and in clarifying the
pathogenesis of uveitis in childhood.
Study design
We will analyze the relation between protein profiles in the aqueous humor and
the type of uveitis. Furthermore, tissue fragments of the iris and ciliary body
of children with uveitis, who are operated on for secondary glaucoma, will be
analyzed on the presence of inflammatory infiltrates. The tissue
characteristics will be related to the cause of the intraocular inflammation
and visual prognosis.
Study burden and risks
The treatment and therapy of the patients remains unchanged. Material will only
be collected during a therapeutically necessary glaucoma or cataract surgery.
Aqueous humor and possibly tissue fragments, which otherwise would be lost
during surgery, will be collected. The cataract or glaucoma surgery will remain
unchanged. When the child is under general anesthesia a venous punction (10ml)
under sterile circumstances will be performed. The patient will not notice
anything due to the anesthetics.
Heidelberglaan 100
3584 CX Utrecht
Nederland
Heidelberglaan 100
3584 CX Utrecht
Nederland
Listed location countries
Age
Inclusion criteria
Uveitis diagnosed before the age of 16 and cataract or glaucoma surgery
Exclusion criteria
Uveitis diagnosed after the age of 16
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24801.041.08 |