Primary:1. Which outcome variables of oculomotor performance and eye-hand coordinatio are useful to distinguish between Dementia with Lewy bodies, Alzheimerdementia and Parkinsondementia.Secundary:1. What are the base line values for the parameters…
ID
Source
Brief title
Condition
- Neurological disorders NEC
- Dementia and amnestic conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Eye movements:
- Latency (defined as the time between the display of the visual stimulus and
the start of the eye movement (in milliseconds))
- Eye velocity (degrees of arc per second)
- Gaze direction accuracy or "gain" (degrees of arc)
- Number of errors in the tasks performed
Eye-hand coordination:
- Response time (defined as the time between the saccade and the start of the
hand movement (in milliseconds))
- Duration of the movement itself (in milliseconds)
- Distance traveled from start position to the target (in centimeters)
- Peak velocity of hand movement (meters per second)
- Number of errors in the tasks performed.
All outcome measurements will be compared with the results of the healthy
subjects. Also, the results between the groups themselves will be compared.
Secondary outcome
Not applicable
Background summary
Prevalence studies and reviews state DLB as the third or second most common
dementia, respectively. This indicates that there are still some difficulties
diagnosing DLB correctly. Meaning that discriminating between DLB, AD and PDD
in the clinical setting is not yet optimized. To bridge this gap is of great
importance for future research and therapeutic options.
Previous research found differences in oculomotor performance between frontal
dementia and Alzheimer dementia. Also deviations in eye movements have been
found in DLB. In early ALzheimer deviations in eye-hand coordination have been
found even before memory problems.
Our hypothesis states that by measuring oculomotor performance and eye-hand
coordination differences in outcome measures will be found between Dementia
with Lewy bodies, Alzheimer dementia and Parkinson dementia.
Study objective
Primary:
1. Which outcome variables of oculomotor performance and eye-hand coordinatio
are useful to distinguish between Dementia with Lewy bodies, Alzheimerdementia
and Parkinsondementia.
Secundary:
1. What are the base line values for the parameters examined?
2. Is this method applicable and reproducible?
3. To what extent is there an agreement between the results and severity of
pathology as previously established with neuropsychological testing?
4.To what extent is visuomotor integration affected?
5.To what extent is the spatial ability impaired?
6. Can conclusions be drawn from the abnormalities in these parameters with
regard to the localization of anatomical pathology?
Study design
Experimental / Test development
Study burden and risks
Low.
The risks of this research are negligible. There will be little intervention
and the investigation is not invasive. The only possibility is that the
subject gets frustrated because he is unable to complete a task. But the
expectation is that this will be minimal, since only subjects with mild
cognitive problems will be enrolled. Moreover, the test may be interrupted if
desired.
Dr. Molewaterplein 50
3015 GE Rotterdam
Nederland
Dr. Molewaterplein 50
3015 GE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Age 60 years or older
Persons with a diagnosed with a probable Dementie with Lewy bodies, Alzheimer dementia or Parkinson dementia.
Exclusion criteria
Comorbities; neurologic disorders in particular
Oculair pathology
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL25284.078.08 |