To characterise the phosphoester profile in brain tumours and to investigate the differences in composition of (glycerol)phosphocholine and (glycerol)phosphoethanolamine tissue levels.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
hersen tumoren
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
In this study we try to characterise the phosphoester content in brain
tumours. The main study parameters are the peak areas of the (glycerol)choline
and (glycerol)ethanolamine in the 31P MR spectrum.
Secondary outcome
1H MRS spectra.
Background summary
From animal and cell culture studies it appears that the phosphor mono and
di-ester content in tumours is different from that in the normal brain tissue
and that these molecules might be markers for tumour, malignancy and tumour
respons to therapy. We have developed a new technique to study in particular
the (glycerol)phophocholine and (glycerol)phosphorethanolamine compounds in
vivo in the human brain in a non-invasive way. More insight into the choline
metabolism of tumours might be important for tumour diagnosis and treatment
follow up.
Study objective
To characterise the phosphoester profile in brain tumours and to investigate
the differences in composition of (glycerol)phosphocholine and
(glycerol)phosphoethanolamine tissue levels.
Study design
This is an observational study. Patients will be examined only once. The data
will be analyzed.
Study burden and risks
Patients undergo an MRS examination. They have to lie down in the MR scanner
for approximately 60 minutes, with their head in a coil. This head coil is a
little different from the standard manufacturer coils because the patient
cannot look through it, he/she can only look through a small * window* but it
fullfills the same safety requirements.
Geert Groote plein 10
6500 HB Nijmegen
Nederland
Geert Groote plein 10
6500 HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
patients with a glial tumour and without MRI contra-indication
Exclusion criteria
patients with MRI contra-indication. patients that are claustrofobic. Patients with pacemakers or neurostimulators. Patients with large metal implants
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24743.091.08 |