To investigate the value of ancillary diagnostic investigations, more specific MRI, 123I-MIBG scintigraphy, ultrasound examination of the basal ganglia and analysis of cerebrospinal fluids to differentiate Parkinson's disease and the Atypical…
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary outcome will be value of the individual investigations to establish the
diagnosis: Parkinson's Disease or Atypical Parkinsonian Disorder
Secondary outcome
Secundary outcome might be the diffentiation between the different subtypes of
Atypical Parkinsonian Disorder
Background summary
Parkinson's Disease and the Atypical Parkinsonian Disorder (like Multiple
System Atrophy, Progressive Supranuclear Palsy, Corticobasal Degeneration, Lewy
Body Dementia) are disease entities with partly common symptomatology.
Especially very early in the course of disease, the differentiation between
both disease entities can be challenging, even for specialists in the field of
movement disorder. However, the establishment of a correct diagnosis is very
important for adequate patientcounseling, treatment and the correct inclusion
of patients in research trials. Ancillary diagnostic investigations are looked
upon to aid in this diagnostic dilemma.
Study objective
To investigate the value of ancillary diagnostic investigations, more specific
MRI, 123I-MIBG scintigraphy, ultrasound examination of the basal ganglia and
analysis of cerebrospinal fluids to differentiate Parkinson's disease and the
Atypical Parkisonisonian disorder.
Study design
Prospective, observational study
Study burden and risks
The proposed investigations are, when taken into account the individual
indications and contra-indications, safe and are already used widely as
ancillary investigations. Furthermore, these investigations have shown great
value in the field of Parkinson's Disease, more specifically in the
differentiation between Parkinson's Disease and the Atypical Parkinsonian
Disorder.
Postbus 9101
6500 HB Nijmegen
NL
Postbus 9101
6500 HB Nijmegen
NL
Listed location countries
Age
Inclusion criteria
Parkinsonism
Exclusion criteria
o Diagnosis *probable PD*
o Diagnosis *probable MSA*
o Diagnosis *probable PSP*
o Diagnosis *CBD*
o Diagnosis *DLB*
o Diagnosis *probable Vasculair Parkinsonisme*
o Cerebral disease other than neurodegenerative parkinsonism
o Brain surgery in medical history
o Severe co-morbitidy
o Furthermore, each diagnostic tests has individual contra-indications, which will be applied to all patients.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30828.091.09 |