The main objective of this project will be to increase our knowledge of the neuronal basis of attentionalproblems in neurodevelopmental disorders, espacially ADHD and autism spectrumdisorders (ASD). Our findings will contribute to the development of…
ID
Source
Brief title
Condition
- Developmental disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Alpha-lateralization index
Secondary outcome
Not applicable.
Background summary
Attentiondeficit/hyperactivity disorder has a high prevalence world-wide. The
neuronal substrate for this disorder is not clear. Alpha oscillation have been
shown to play an important part in directing attention. Although study show
aberent alpha oscillations in patients with ADHD, this finding has not been
related to attention function yet. With magneto-encephalography (MEG) methods
alpha-lateralization during attention tasks can be observed. Using these
methods we can study alpha oscillations during an attention task in patients
with ADHD. Because attentionproblems are also commen in other psychiatric
disorders, it is relevant to investigate how specific our findings are to ADHD.
Therefore patients with autism spectrum disorder, a neurodevelopmental disorder
that is also characterized by attentionproblems, will be studied aswell.
Study objective
The main objective of this project will be to increase our knowledge of the
neuronal basis of attentionalproblems in neurodevelopmental disorders,
espacially ADHD and autism spectrumdisorders (ASD). Our findings will
contribute to the development of beter diagnistic and intervention methods in
the future.
Study design
Alpha activity will be measured during a directed attention task using
magneto-encephalography. Alpha-lateralization will be calculated and compared
between groups.
Study burden and risks
The MEG measurements will take approxemately 60 minutes in total, a practice
session included. Questionairs will take 30 minutes. Particepants will invest a
total of 2 hours of their time. The proposed study includes brain imaging
procedures that are no burden to subject and have already been applied to a
very large scale in normal subjects and in subjects with various conditions
(including ADHD and ASD), without side-effects or unwanted effects.
Reinierpostlaan 6
6525 GC Nijmegen
NL
Reinierpostlaan 6
6525 GC Nijmegen
NL
Listed location countries
Age
Inclusion criteria
For all groups inclusion criteria will be: (1) Age between 20 and 40 years old. (2) Estimated IQ above 80. In the ADHD group subjects should be diagnosed with ADHD, combined type, based on psychiatric consultation and meet DSM criteria for ADHD as specified in DSM-IV and have a clinical score on the Conners* Rating Scale Revised (CRS-R). In the ASD group subjects should be diagnosed with autism based on psychiatric consultation and meet DSM criteria for autistic disorder or Aspergers Syndrome as specified in DSM-IV and have a clinical score on the autism diagnostic interview revised (ADI-R).
Exclusion criteria
For all groups exclusion criteria will be: (1) (Co-morbid) psychiatric or neurological disorders. (2) The use of psychotropic medication except for psychostimulants (methylphenidate). Symptomatology should tolerate temporal seizure of psychostimulant-use (see *ethical considerations* in researchprotocol).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL29906.091.09 |